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CXCL15: Wikis

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Cxcl15 chemokine (C-X-C motif) ligand 15
Identifiers
Symbols Cxcl15; weche; Scyb15; lungkine; Cxcl15
External IDs MGI1339941
Orthologs
Species Human Mouse
Entrez n/a 20309
Ensembl n/a ENSMUSG00000029375
UniProt n/a Q9WVL7
RefSeq (mRNA) n/a NM_011339
RefSeq (protein) n/a NP_035469
Location (UCSC) n/a Chr 5:
91.22 - 91.23 Mb
PubMed search n/a [1]

Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR+ CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung,[1] and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland.[2] The gene for CXCL15 is found on mouse chromosome 5.

References

  1. ^ Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol 162 (9): 5490–7. PMID 10228029.  
  2. ^ Schmitz J, McCracken V, Dimmitt R, Lorenz R. "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem. PMID 17242461.  
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