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Chemokine (C-X-C motif) ligand 5
Symbols CXCL5; ENA-78; SCYB5
External IDs OMIM600324 HomoloGene88672 GeneCards: CXCL5 Gene
RNA expression pattern
PBB GE CXCL5 214974 x at tn.png
PBB GE CXCL5 215101 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6374 n/a
Ensembl ENSG00000163735 n/a
UniProt P42830 n/a
RefSeq (mRNA) NM_002994 n/a
RefSeq (protein) NP_002985 n/a
Location (UCSC) Chr 4:
75.08 - 75.08 Mb
PubMed search [1] n/a

C-X-C motif chemokine 5 is a protein that in humans is encoded by the CXCL5 gene.[1][2]

The protein encoded by this gene, CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha.[3] Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-γ.[4] This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.[4] The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes.[3][5] CXCL5 has been implicated in connective tissue remodelling.[4]


  1. ^ Chang MS, McNinch J, Basu R, Simonet S (Nov 1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J Biol Chem 269 (41): 25277-82. PMID 7929219.  
  2. ^ "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5".  
  3. ^ a b Chang MS, McNinch J, Basu R, Simonet S (1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J. Biol. Chem. 269 (41): 25277–82. PMID 7929219.  
  4. ^ a b c Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A (2003). "Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils". Clin. Exp. Allergy 33 (4): 531–7. doi:10.1046/j.1365-2222.2003.01609.x. PMID 12680872.  
  5. ^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1-2): 39–42. doi:10.1159/000015209. PMID 10343098.  

Further reading

  • Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007). "A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5.". J. Immunol. 179 (7): 4849–56. PMID 17878384.  
  • Walz A, Schmutz P, Mueller C, Schnyder-Candrian S (1997). "Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease.". J. Leukoc. Biol. 62 (5): 604–11. PMID 9365115.  
  • Struyf S, Proost P, Van Damme J (2004). "Regulation of the immune response by the interaction of chemokines and proteases.". Adv. Immunol. 81: 1–44. doi:10.1016/S0065-2776(03)81001-5. PMID 14711052.  
  • Walz A, Burgener R, Car B, et al. (1992). "Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8.". J. Exp. Med. 174 (6): 1355–62. doi:10.1084/jem.174.6.1355. PMID 1744577.  
  • Power CA, Furness RB, Brawand C, Wells TN (1995). "Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets.". Gene 151 (1-2): 333–4. doi:10.1016/0378-1119(94)90682-3. PMID 7828901.  
  • Corbett MS, Schmitt I, Riess O, Walz A (1995). "Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78).". Biochem. Biophys. Res. Commun. 205 (1): 612–7. doi:10.1006/bbrc.1994.2709. PMID 7999089.  
  • Koch AE, Kunkel SL, Harlow LA, et al. (1994). "Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis.". J. Clin. Invest. 94 (3): 1012–8. doi:10.1172/JCI117414. PMID 8083342.  
  • Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). "Chemokine and chemokine receptor mRNA expression in human platelets.". Cytokine 7 (6): 479–82. doi:10.1006/cyto.1995.0065. PMID 8580362.  
  • Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor.". J. Biol. Chem. 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798.  
  • Keates S, Keates AC, Mizoguchi E, et al. (1997). "Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis.". Am. J. Physiol. 273 (1 Pt 1): G75–82. PMID 9252512.  
  • Wuyts A, Proost P, Lenaerts JP, et al. (1998). "Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78.". Eur. J. Biochem. 255 (1): 67–73. doi:10.1046/j.1432-1327.1998.2550067.x. PMID 9692902.  
  • Wyrick PB, Knight ST, Paul TR, et al. (1999). "Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis.". J. Infect. Dis. 179 (4): 954–66. doi:10.1086/314676. PMID 10068592.  
  • Wuyts A, Govaerts C, Struyf S, et al. (1999). "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.". Eur. J. Biochem. 260 (2): 421–9. doi:10.1046/j.1432-1327.1999.00166.x. PMID 10095777.  
  • Hogaboam CM, Bone-Larson CL, Steinhauser ML, et al. (1999). "Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines.". Faseb J. 13 (12): 1565–74. PMID 10463948.  
  • Luu NT, Rainger GE, Nash GB (2000). "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils.". J. Immunol. 164 (11): 5961–9. PMID 10820279.  
  • Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV (2000). "Control of chemokine production at the blood-retina barrier.". Immunology 101 (3): 426–33. doi:10.1046/j.0019-2805.2000.01105.x. PMID 11106948.  
  • Zhang C, Thornton MA, Kowalska MA, et al. (2001). "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus.". Blood 98 (3): 610–7. doi:10.1182/blood.V98.3.610. PMID 11468158.  
  • Chandrasekar B, Melby PC, Sarau HM, et al. (2003). "Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway.". J. Biol. Chem. 278 (7): 4675–86. doi:10.1074/jbc.M207006200. PMID 12468547.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  


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