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Chemokine (C-X-C motif) receptor 6
External IDs OMIM605163 MGI1934582 HomoloGene38197 IUPHAR: CXCR6 GeneCards: CXCR6 Gene
RNA expression pattern
PBB GE CXCR6 206974 at tn.png
PBB GE CXCR6 211469 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10663 80901
Ensembl ENSG00000172215 ENSMUSG00000048521
UniProt O00574 n/a
RefSeq (mRNA) NM_006564 NM_030712
RefSeq (protein) NP_006555 NP_109637
Location (UCSC) Chr 3:
45.96 - 45.96 Mb
Chr 9:
123.66 - 123.66 Mb
PubMed search [1] [2]

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[1][2][3]

CXCR6 has also recently been designated CD186 (cluster of differentiation 186).


  1. ^ Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM (Jun 1997). "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1". J Exp Med 185 (11): 2015-23. PMID 9166430.  
  2. ^ Deng HK, Unutmaz D, KewalRamani VN, Littman DR (Aug 1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature 388 (6639): 296-300. doi:10.1038/40894. PMID 9230441.  
  3. ^ "Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6".  

External links

Further reading

  • Ruibal-Ares BH, Belmonte L, Baré PC, et al. (2004). "HIV-1 infection and chemokine receptor modulation.". Curr. HIV Res. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339.  
  • Loetscher M, Amara A, Oberlin E, et al. (1998). "TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function.". Curr. Biol. 7 (9): 652–60. doi:10.1016/S0960-9822(06)00292-2. PMID 9285716.  
  • Hoffman TL, Stephens EB, Narayan O, Doms RW (1998). "HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11360–5. doi:10.1073/pnas.95.19.11360. PMID 9736741.  
  • Schramm B, Penn ML, Speck RF, et al. (2000). "Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease.". J. Virol. 74 (1): 184–92. PMID 10590105.  
  • Tscherning-Casper C, Vödrös D, Menu E, et al. (2000). "Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1.". J. Acquir. Immune Defic. Syndr. 24 (1): 1–9. PMID 10877489.  
  • Ignatius R, Wei Y, Beaulieu S, et al. (2000). "The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells.". AIDS Res. Hum. Retroviruses 16 (11): 1055–9. doi:10.1089/08892220050075318. PMID 10933620.  
  • Unutmaz D, Xiang W, Sunshine MJ, et al. (2000). "The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse.". J. Immunol. 165 (6): 3284–92. PMID 10975845.  
  • Matloubian M, David A, Engel S, et al. (2001). "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.". Nat. Immunol. 1 (4): 298–304. doi:10.1038/79738. PMID 11017100.  
  • Wilbanks A, Zondlo SC, Murphy K, et al. (2001). "Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines.". J. Immunol. 166 (8): 5145–54. PMID 11290797.  
  • Lee B, Leslie G, Soilleux E, et al. (2001). "cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor.". J. Virol. 75 (24): 12028–38. doi:10.1128/JVI.75.24.12028-12038.2001. PMID 11711593.  
  • Calabresi PA, Yun SH, Allie R, Whartenby KA (2002). "Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells.". J. Neuroimmunol. 127 (1-2): 96–105. doi:10.1016/S0165-5728(02)00106-6. PMID 12044980.  
  • Kim CH, Johnston B, Butcher EC (2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.". Blood 100 (1): 11–6. doi:10.1182/blood-2001-12-0196. PMID 12070001.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Duggal P, An P, Beaty TH, et al. (2004). "Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans.". Genes Immun. 4 (4): 245–50. doi:10.1038/sj.gene.6363950. PMID 12761559.  
  • Koprak S, Matheravidathu S, Springer M, et al. (2003). "Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin.". Cell. Immunol. 223 (1): 1–12. doi:10.1016/S0008-8749(03)00130-8. PMID 12914753.  
  • Shimaoka T, Nakayama T, Fukumoto N, et al. (2004). "Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells.". J. Leukoc. Biol. 75 (2): 267–74. doi:10.1189/jlb.1003465. PMID 14634054.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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