The Full Wiki

More info on Calcifediol

Calcifediol: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Calcifediol
Calcidiol2.svg
IUPAC name
Other names 25-Hydroxyvitamin D3
25-Hydroxycholecalciferol
Calcifediol
Identifiers
CAS number 19356-17-3 Yes check.svgY
PubChem 5283731
MeSH Calcifediol
SMILES
InChI
InChI key JWUBBDSIWDLEOM-BNQRRPJDBR
ChemSpider ID 4938806
Properties
Molecular formula C27H44O2
Molar mass 400.64 g/mol
 Yes check.svgY (what is this?)  (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a prehormone which is produced by hydroxylation of vitamin D3 (cholecalciferol) in the liver. Calcidiol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation.[1][2]

Clinical significance

In medicine, blood concentration of calcidiol is considered the best indicator of vitamin D status.[3] It is the most sensitive measure,[4] though experts have called for improved standardization and reproducibility across different laboratories.[3] The normal range varies widely depending on several factors, including age and geographic location. A broad reference range of 20–150 nmol/L has been suggested,[5] while several studies have defined levels below 80 nmol/L as indicative of vitamin D deficiency.[6]

Increasing calcidiol levels are associated with increasing fractional absorption of calcium from the gut up to levels of 80 nmol/L (32 ng/mL). Urinary calcium excretion balances intestinal calcium absorption and does not increase with calcidiol levels up to ~400 nmol/L (160 ng/mL).[7]

References

  1. ^ Bender, David A.; Mayes, Peter A (2006). "Micronutrients: Vitamins & Minerals". in Victor W. Rodwell; Murray, Robert F.; Harper, Harold W.; Granner, Darryl K.; Mayes, Peter A.. Harper's Illustrated Biochemistry. New York: Lange/McGraw-Hill. pp. 492–3. ISBN 0-07-146197-3. http://books.google.com.br/books?id=QrJCZ1v5T6AC.   Retrieved December 10, 2008 through Google Book Search.
  2. ^ Institute of Medicine (1997). "Vitamin D". Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, D.C: National Academy Press. pp. 254. ISBN 0-309-06403-1. http://www.nap.edu/openbook.php?record_id=5776&page=250.  
  3. ^ a b Heaney, Robert P (Dec 2004). "Functional indices of vitamin D status and ramifications of vitamin D deficiency". American Journal of Clinical Nutrition 80 (6): 1706S-1709S. http://www.ajcn.org/cgi/content/full/80/6/1706S.  
  4. ^ Institute of Medicine (1997), p. 259
  5. ^ Bender, David A. (2003). "Vitamin D". Nutritional biochemistry of the vitamins. Cambridge: Cambridge University Press. ISBN 0-521-80388-8. http://books.google.com.br/books?id=pxEJNs0IUo4C.   Retrieved December 10, 2008 through Google Book Search.
  6. ^ Hollis BW (February 2005). "Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D". J Nutr 135 (2): 317–22. PMID 15671234. http://jn.nutrition.org/cgi/pmidlookup?view=long&pmid=15671234.  
  7. ^ Kimball et al. (2004). "Safety of vitamin D3 in adults with multiple sclerosis". J Clin Endocrinol Metab. PMID 17823429.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message