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Cancell, also called Protocel, Sheridan's Formula, Jim's Juice, Crocinic Acid, JS–114, JS–101, 126–F, Cantron, and Entelev, is a formula that has been promoted as a treatment for a wide range of diseases, including cancer, and is available in both liquid and capsule variations. Originally called Entelev, the formula was developed by biochemist James V. Sheridan. Sheridan sought to target the primarily anaerobic cell respiration of cancer cells (in accordance with the theories of Otto Warburg), claiming to lower cell potential leading to the destruction of cancer cells. The individual ingredients of Cancell were tested by the National Cancer Institute and found to be ineffective against cancer,^[1] though Cancell continues to be marketed as a dietary supplement in the U.S.

Formulation and efficacy

The exact composition of Cancell/Cantron/Protocel is unknown. The U.S. Food and Drug Administration (FDA) has listed the components as inositol, nitric acid, sodium sulfite, potassium hydroxide, sulfuric acid, and catechol. The original manufacturer also identified "crocinic acid" as a component; however, information about the nature and origin of this chemical has not been provided, and it does not appear to be a known compound.

The National Cancer Institute (NCI) tested the constituents of Cancell in animal experiments in 1978 and 1980 and in vitro on human tumors in 1990 and 1991. They concluded that the compounds comprising Cancell could not be taken in doses high enough to kill cancer cells in the body, and that further study was not warranted. No peer-reviewed clinical or animal trials of Cancell have demonstrated any positive effect; claims for Cancell's efficacy—if any—are limited solely to anecdotal reports and testimonials.^[1] The American Cancer Society recommends against the use of CanCell, as there is no evidence that it is effective in treating cancer.^[2]

Legal status

Injunction proceedings were instigated by the FDA in June 1987 for manufacturing compliance violations and failure to maintain complaints files. A complaint for permanent injunction was filed February 21, 1989 in the U.S. District Court for the Eastern District of Michigan to enjoin Sheridan and Edward J. Sopcak from distributing CanCell. At a hearing in November 1992, the Court found Sopcak to be in civil contempt and ordered him to comply with the injunction immediately.^[3]

Cancell is currently distributed as a dietary supplement under the names Protocel and Cantron, and is not approved by the FDA for use as a cancer treatment in the United States.

References

External links

• Cancell entry in the public domain NCI Dictionary of Cancer Terms
• "Questions and Answers About Cancell". National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/cam/cancell/Patient/page2.  
• Questionable methods of cancer management: Cancell/Entelev, from the American Cancer Society

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".