Candidiasis: Wikis

  
  

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Candidiasis
Classification and external resources

Agar plate culture of Candida albicans
ICD-10 B37.
ICD-9 112
DiseasesDB 1929
MedlinePlus 001511
eMedicine med/264 emerg/76 ped/312 derm/67
MeSH D002177

Candidiasis or thrush is a fungal infection (mycosis) of any of the Candida species, of which Candida albicans is the most common.[1][2] Candidiasis encompasses infections that range from superficial, such as oral thrush and vaginitis, to systemic and potentially life-threatening diseases. Candida infections of the latter category are also referred to as candidemia and are usually confined to severely immunocompromised persons, such as cancer, transplant, and AIDS patients.

Superficial infections of skin and mucosal membranes by Candida causing local inflammation and discomfort are however common in many human populations.[2][3][4] While clearly attributable to the presence of the opportunistic pathogens of the genus Candida, candidiasis describes a number of different disease syndromes that often differ in their causes and outcomes.[2][3] Commonly referred to as a yeast infection, it is also technically known as candidosis, moniliasis, and oidiomycosis.[5]:308

Contents

Classification

Candidiasis may be divided into the following types:[5]:308-311

Signs and symptoms

Most candidial infections are treatable and result in minimal complications such as redness, itching and discomfort, though complication may be severe or fatal if left untreated in certain populations. In immunocompetent persons, candidiasis is usually a very localized infection of the skin or mucosal membranes, including the oral cavity (thrush), the pharynx or esophagus, the gastrointestinal tract, the urinary bladder, or the genitalia (vagina, penis).[1]

Candidiasis is a very common cause of vaginal irritation, or vaginitis, and can also occur on the male genitals. In immunocompromised patients, Candida infections can affect the esophagus with the potential of becoming systemic, causing a much more serious condition, a fungemia called candidemia.[3][4]

Children, mostly between the ages of three and nine years of age, can be affected by chronic mouth yeast infections, normally seen around the mouth as white patches. However, this is not a common condition.

Symptoms of candidiasis may vary depending on the area affected. Infection of the vagina or vulva may cause severe itching, burning, soreness, irritation, and a whitish or whitish-gray cottage cheese-like discharge, often with a curd-like appearance. These symptoms are also present in the more common bacterial vaginosis. In a 2002 study published in the Journal of Obstetrics and Gynecology, only 33 percent of women who were self-treating for a yeast infection actually had a yeast infection, while most had either bacterial vaginosis or a mixed-type infection. Symptoms of infection of the male genitalia include red patchy sores near the head of the penis or on the foreskin, severe itching, or a burning sensation. Candidiasis of the penis can also have a white discharge, although uncommon. However, having no symptoms at all is common, and a more severe form of the symptoms may emerge later.

Causes

Oral candidiasis on the tongue and soft palate.

Candida yeasts are commonly present in humans, and their growth is normally limited by the human immune system and by other microorganisms, such as bacteria occupying the same locations (niches) in the human body [6]

In a study of 1009 women in New Zealand, C. albicans was isolated from the vaginas of 19% of apparently healthy women, i.e., those that experienced few or no symptoms of infection. External use of detergents or douches or internal disturbances (hormonal or physiological) can perturb the normal vaginal flora, consisting of lactic acid bacteria, such as lactobacilli, and result in an overgrowth of Candida cells causing symptoms of infection, such as local inflammation.[7] Pregnancy and the use of oral contraceptives have been reported as risk factors,[8] while the roles of engaging in vaginal sex immediately and without cleansing after anal sex and using lubricants containing glycerin remain controversial. Diabetes mellitus and the use of anti-bacterial antibiotics are also linked to an increased incidence of yeast infections.[8] Diet has been found to affect rates of symptomatic Candidiases in some animal infection models, [9] and hormone replacement therapy and infertility treatments may also be predisposing factors.[10]

A weakened or undeveloped immune system or metabolic illnesses such as diabetes are significant predisposing factors of candidiasis.[11] Diseases or conditions linked to candidiasis include HIV/AIDS, mononucleosis, cancer treatments, steroids, stress, and nutrient deficiency. Almost 15% of people with weakened immune systems develop a systemic illness caused by Candida species. In extreme cases, these superficial infections of the skin or mucous membranes may enter into the bloodstream and cause systemic Candida infections.

In penile candidiasis, the causes include sexual intercourse with an infected individual, low immunity, antibiotics, and diabetes. Male genital yeast infection is less common, and incidence of infection is only a fraction of that in women; however, yeast infection on the penis from direct contact via sexual intercourse with an infected partner is not uncommon.[12]

Diagnosis

Micrograph of esophageal candidiasis. Biopsy specimen; PAS stain.

Diagnose of a yeast infections is done either via microscopic examination or culturing.

For identification by light microscopy, a scraping or swab of the affected area is placed on a microscope slide. A single drop of 10% potassium hydroxide (KOH) solution is then added to the specimen. The KOH dissolves the skin cells but leaves the Candida cells intact, permitting visualization of pseudohyphae and budding yeast cells typical of many Candida species.

For the culturing method, a sterile swab is rubbed on the infected skin surface. The swab is then streaked on a culture medium. The culture is incubated at 37 °C for several days, to allow development of yeast or bacterial colonies. The characteristics (such as morphology and colour) of the colonies may allow initial diagnosis of the organism that is causing disease symptoms.

Treatment

Candida species are frequently part of the human body's normal oral and intestinal flora. Treatment with antibiotics can lead to eliminating the yeast's natural competitors for resources, and increase the severity of the condition.

In clinical settings, candidiasis is commonly treated with antimycotics—the antifungal drugs commonly used to treat candidiasis are topical clotrimazole, topical nystatin, fluconazole, and topical ketoconazole.

For example, a one-time dose of fluconazole (as Diflucan 150-mg tablet taken orally) has been reported as being 90% effective in treating a vaginal yeast infection. [13] (Care should be taken by people who have allergic reactions to azole group of medicines. And this medicine has different levels of contraditory reactions with other medicines as well. ) This dose is only effective for vaginal yeast infections, and other types of yeast infections may require different treatments. In severe infections (generally in hospitalized patients), amphotericin B, caspofungin, or voriconazole may be used. Local treatment may include vaginal suppositories or medicated douches. Gentian violet can be used for breastfeeding thrush, but when used in large quantities it can cause mouth and throat ulcerations in nursing babies, and has been linked to mouth cancer in humans and to cancer in the digestive tract of other animals.[14]

C. albicans can develop resistance to antimycotic drugs, [15] such as fluconazole, one of the drugs that is often used to treat candidiasis. Recurring infections may be treatable with other anti-fungal drugs, but resistance to these alternative agents may also develop.

History

The genus Candida and species C. albicans was described by botanist Christine Marie Berkhout in her doctoral thesis at the University of Utrecht in 1923. Over the years, the classification of the genera and species has evolved. Obsolete names for this genus include Mycotorula and Torulopsis. The species has also been known in the past as Monilia albicans and Oidium albicans. The current classification is nomen conservandum, which means the name is authorized for use by the International Botanical Congress (IBC).[16]

The genus Candida includes about 150 different species, however, only a few are known to cause human infections: C. albicans is the most significant pathogenic species. Other Candida species pathogenic in humans include C. tropicalis, C. glabrata, C. krusei, C. parapsilosis, C. dubliniensis, and C. lusitaniae.

Society and culture

Some alternative medicine proponents postulate a widespread occurrence of "systemic candidiasis" (or candida hypersensitivity syndrome, yeast allergy, or gastrointestinal candida overgrowth). The view was most widely promoted in a book published by Dr. William Crook,[17] which hypothesized that a variety of common symptoms such as fatigue, PMS, sexual dysfunction, asthma, psoriasis, digestive and urinary problems, multiple sclerosis, and muscle pain, could be caused by subclinical infections of Candida albicans. Crook suggested a variety of remedies to treat these symptoms, ranging from dietary modification, prescription antifungals, to colonic irrigation. With the exception of the few dietary studies in the urinary tract infection section conventional medicine has not used most of these alternatives, since there is limited scientific evidence to prove their effectiveness, or that subclinical "systemic candidiasis" is a viable diagnosis.[18][19][20][21]

References

  1. ^ a b Walsh TJ, Dixon DM (1996). "Deep Mycoses". in Baron S et al. eds. (via NCBI Bookshelf). Baron's Medical Microbiology (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.4006.  
  2. ^ a b c MedlinePlus Encyclopedia Vaginal yeast infection
  3. ^ a b c Fidel PL (2002). "Immunity to Candida". Oral Dis. 8: 69–75. doi:10.1034/j.1601-0825.2002.00015.x. PMID 12164664.  
  4. ^ a b Pappas PG (2006). "Invasive candidiasis". Infect. Dis. Clin. North Am. 20 (3): 485–506. doi:10.1016/j.idc.2006.07.004. PMID 16984866.  
  5. ^ a b James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.  
  6. ^ Mulley, A. G.; Goroll, A. H. (2006). Primary Care Medicine: office evaluation and management of the adult patient. Philadelphia: Wolters Kluwer Health. pp. 802–3. ISBN 0-7817-7456-X. http://books.google.com/books?id=aWQhTbwoM9EC&pg=RA1-PA802&lpg=RA1-PA802. Retrieved 2008-11-23.  
  7. ^ Mårdh P A, Novikova N, Stukalova E (October 2003). "Colonisation of extragenital sites by Candida in women with recurrent vulvovaginal candidosis". BJOG 110 (10): 934–7. PMID 14550364. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1470-0328&date=2003&volume=110&issue=10&spage=934.  
  8. ^ a b Schiefer HG (1997). "Mycoses of the urogenital tract". Mycoses 40 Suppl 2: 33–6. PMID 9476502.  
  9. ^ Yamaguchi N, Sonoyama K, Kikuchi H, Nagura T, Aritsuka T, Kawabata J (January 2005). "Gastric colonization of Candida albicans differs in mice fed commercial and purified diets". J. Nutr. 135 (1): 109–15. PMID 15623841. http://jn.nutrition.org/cgi/pmidlookup?view=long&pmid=15623841.  
  10. ^ Nwokolo N C, Boag F C (May 2000). "Chronic vaginal candidiasis. Management in the postmenopausal patient". Drugs Aging 16 (5): 335–9. PMID 10917071.  
  11. ^ Odds FC (1987). "Candida infections: an overview". Crit. Rev. Microbiol. 15 (1): 1–5. doi:10.3109/10408418709104444. PMID 3319417.  
  12. ^ David LM, Walzman M, Rajamanoharan S (October 1997). "Genital colonisation and infection with candida in heterosexual and homosexual males". Genitourin Med 73 (5): 394–6. PMID 9534752.  
  13. ^ Moosa MY, Sobel JD, Elhalis H, Du W, Akins RA (2004). "Fungicidal activity of fluconazole against Candida albicans in a synthetic vagina-simulative medium". Antimicrob. Agents Chemother. 48 (1): 161–7. doi:10.1128/AAC.48.1.161-167.2004. PMID 14693534.  
  14. ^ Craigmill A (December 1991). "Gentian Violet Policy Withdrawn". Cooperative Extension University of California -- Environmental Toxicology Newsletter 11 (5). http://extoxnet.orst.edu/newsletters/n115_91.htm.  
  15. ^ Cowen LE, Nantel A, Whiteway MS (July 2002). "Population genomics of drug resistance in Candida albicans". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9284–9. doi:10.1073/pnas.102291099. PMID 12089321.  
  16. ^ "International Code of Botanical Nomenclature". Königstein. 2000. http://www.bgbm.org/iapt/nomenclature/code/SaintLouis/0000St.Luistitle.htm. Retrieved 2008-11-23.  
  17. ^ Crook, William G. (1986). The yeast connection: a medical breakthrough. New York: Vintage Books. ISBN 0394747003.  
  18. ^ Weil A (2002-10-25). "Concerned About Candidiasis?". Weil Lifestyle. http://www.drweil.com/u/QA/QA125503/. Retrieved 2008-02-21.  
  19. ^ Barrett S (2005-10-08). "Dubious "Yeast Allergies"". QuackWatch. http://www.quackwatch.org/01QuackeryRelatedTopics/candida.html. Retrieved 2008-02-21.  
  20. ^ Katherine Zeratsky. "Candida cleanse: Does it treat candidiasis?". Mayo Clinic. http://www.mayoclinic.com/health/candida-cleanse/AN01679. Retrieved 2009-08-09.  
  21. ^ Edward Blonz (1986-12-12). "Is There an Epidemic of Chronic Candidiasis in Our Midst?". JAMA. http://jama.ama-assn.org/cgi/content/summary/256/22/3138?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=chronic+candidiasis&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT. Retrieved 2009-08-09.  

External links


Simple English

Candidiasis
Classification and other resource links
Agar plate culture of Candida albicans
ICD-10 B37.
ICD-9 112
DiseasesDB 1929
MedlinePlus 001511
eMedicine med/264  emerg/76 ped/312 derm/67
MeSH D002177

Candidiasis, often called yeast infection or thrush, is a type of infectious disease. It is a fungal infection (mycosis). The disease is caused by any of the Candida species of yeast. Candida albicans is the most common species.[1][2]

Contents

Causes

Candida yeasts are common in most people. The yeast is usually controlled in the body. When the yeast grows without control, an infection happens.

A weakened, unhealthy, or young immune system may cause Candidiasis. [3] HIV/AIDS, cancer treatments, steroids, stress and not enough nutrients may cause candidiasis.

Antibiotic and steroid use are the most common reason for uncontrolled yeast. [4] Antibiotic kills the good bacteria which control the yeast - the change you'll get the yeast increases because of it.

The Candida fungus grows best in warm, moist and dark places.

Esophageal candidiasis

Esophageal candidiasis is an infection of the esophagus by Candida albicans. The disease happens in unhealthy people. Sometimes people will get the infection when they are done with chemotherapy. People with AIDS can also get this infection more often.

Signs and Symptoms

One sign of esophageal candidiasis is painful swallowing. Weight loss can happen when a person has esophageal candidiasis for a long time.

Oral candidiasis

Oral candidiasis is a yeast infection of the mouth.[5] It is located on the mucous membranes of the mouth. It is caused by Candida albicans, Candida glabrata or Candida tropicalis.

Signs

Candida may appear as thick white or cream-coloured areas on mucosal membranes. The infected mucosa of the mouth may look inflamed. In babies the condition is called thrush. For babies, it is usually painless and causes no pain. Adults may experience discomfort or burning sensation.

Body parts

In healthy persons, candidiasis is usually a very small infection of the skin or mucous membranes.[1] These areas include:

Candidiasis is a very common cause of vaginal irritation, or vaginitis. It can also occur on the penis or scrotum. In unhealthy patients, the Candida infection can affect the esophagus. It could get everywhere in the body. This would cause a much more serious health condition, a state called candidemia.[7] [8]

References

  1. 1.0 1.1 Walsh TJ, Dixon DM (1996). Deep Mycoses in: Baron's Medical Microbiology (Baron S et al, eds.) (4th ed. ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1. 
  2. Medline Plus at the U.S. National Library of Medicine
  3. Odds FC (1987). [Expression error: Unexpected < operator "Candida infections: an overview"]. Crit Rev Microbiol. 15: 1-5.. PMID 3319417. 
  4. National Candida Society Article
  5. Medline Plus, http://www.nlm.nih.gov/medlineplus/ency/article/000626.htm 
  6. Wong, Jeremy (2008), Penile Candidiasis - Yes, Yeast Infection in Men, http://www.californiachronicle.com/articles/view/65098 
  7. Pappas PG (2007). [Expression error: Unexpected < operator "Invasive candidiasis"]. Infect Dis Clin North Am. 20: 485-506. PMID 16984866. 
  8. Fidel PL (2002). [Expression error: Unexpected < operator "Immunity to Candida"]. Oral Dis. 8: 69-75. PMID 12164664. 

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