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Capreomycin: Wikis

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Capreomycin
Systematic (IUPAC) name
(3S)-3,6-diamino-N-[[(2 S,5S,8E,11S,15S)-15-amino-11-[(4 R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide; (3S)-3,6-diamino-N-[[(2S,5S,8 E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide
Identifiers
CAS number 11003-38-6
ATC code J04AB30
PubChem 3032400
DrugBank APRD00844
Chemical data
Formula C 25H44N14O8  
Mol. mass 668.706 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Capreomycin is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for tuberculosis. Adverse effects include nephrotoxicity and 8th cranial nerve toxicity.

The drug should not be given with streptomycin or other drugs that may damage the 8th nerve.

It is a cyclic peptide.[1]

References

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