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Carboprost: Wikis


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Systematic (IUPAC) name
(5Z,9α,11α,13E,15S)-9,11,15-trihydroxy-15- methylprosta-5,13-dien-1-oic acid
CAS number 58551-69-2
ATC code G02AD04
PubChem 5284525
DrugBank APRD00847
ChemSpider 4447583
Chemical data
Formula C 21H36O5  
Mol. mass 368.508 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription only
Routes Intravenous
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Carboprost is a synthetic prostaglandin analogue of PGF (specifically, it is 15-methyl-PGF) with oxytocic properties. The trade name of carboprost tromethamine is Hemabate.

Carboprost induces contractions and can trigger abortion in early pregnancy. It also reduces postpartum bleeding. It is used for the treatment of molar pregnancy.

Exert caution in asthmatic patients.

External links

  • MeSH Carboprost
  • Indman P (2004). "Use of carboprost to facilitate hysteroscopic resection of submucous myomas.". J Am Assoc Gynecol Laparosc 11 (1): 68–72. doi:10.1016/S1074-3804(05)60014-X. PMID 15104835.  
  • Vukelić J. "Second trimester pregnancy termination in primigravidas by double application of dinoprostone gel and intramuscular administration of carboprost tromethamine.". Med Pregl 54 (1-2): 11–6. PMID 11436877.  
  • Ippoliti C, Przepiorka D, Mehra R, Neumann J, Wood J, Claxton D, Gajewski J, Khouri I, van Besien K, Andersson B (1995). "Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation.". Urology 46 (6): 811–5. doi:10.1016/S0090-4295(99)80349-5. PMID 7502421.  

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