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Carmofur: Wikis


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Systematic (IUPAC) name
CAS number 61422-45-5
ATC code L01BC04
PubChem 2577
Chemical data
Formula C 11H16FN3O3  
Mol. mass 257.261 g/mol
SMILES eMolecules & PubChem
Synonyms 1-hexylcarbamoyl-5-fluorouracil
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral

Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.


Mechanism of action



Breast Cancer

Colorectal Cancer

Carmofur, in its oral form, has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients. Trials and meta-analyses have confirmed that the drug is effective on patients with this cancer type, extending their survival.[1]

Adverse effects

As fluorouracil, carmofur has been known to induce leukoencephalopathy.[2][3][4]


  1. ^ Junichi S, et al.. Japanese Journal of Clinical Oncology Advance Access originally published online on September 9, 2005 Japanese Journal of Clinical Oncology 2005 35(9):536-544. doi:10.1093/jjco/hyi147  
  2. ^ Yamada T, Okamura S, Okazaki T, et al. (June 1989). "Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature". Asia Oceania J Obstet Gynaecol 15 (2): 161–8. PMID 2667512.  
  3. ^ Mizutani T (February 2008). "[Leukoencephalopathy caused by antineoplastic drugs]" (in Japanese). Brain Nerve 60 (2): 137–41. PMID 18306661.  
  4. ^ Baehring JM, Fulbright RK (May 2008). "Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients". J Neurol Neurosurg Psychiatr 79 (5): 535–9. doi:10.1136/jnnp.2007.123737. PMID 17682013.  


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