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Carmofur
Systematic (IUPAC) name
5-fluoro-N-hexyl-2,4-dioxo-pyrimidine-1-carboxamide
Identifiers
CAS number 61422-45-5
ATC code L01BC04
PubChem 2577
Chemical data
Formula C 11H16FN3O3  
Mol. mass 257.261 g/mol
SMILES eMolecules & PubChem
Synonyms 1-hexylcarbamoyl-5-fluorouracil
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral

Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.

Contents

Mechanism of action

Uses

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Breast Cancer

Colorectal Cancer

Carmofur, in its oral form, has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients. Trials and meta-analyses have confirmed that the drug is effective on patients with this cancer type, extending their survival.[1]

Adverse effects

As fluorouracil, carmofur has been known to induce leukoencephalopathy.[2][3][4]

References

  1. ^ Junichi S, et al.. Japanese Journal of Clinical Oncology Advance Access originally published online on September 9, 2005 Japanese Journal of Clinical Oncology 2005 35(9):536-544. doi:10.1093/jjco/hyi147 http://jjco.oxfordjournals.org/cgi/content/full/35/9/536.  
  2. ^ Yamada T, Okamura S, Okazaki T, et al. (June 1989). "Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature". Asia Oceania J Obstet Gynaecol 15 (2): 161–8. PMID 2667512.  
  3. ^ Mizutani T (February 2008). "[Leukoencephalopathy caused by antineoplastic drugs]" (in Japanese). Brain Nerve 60 (2): 137–41. PMID 18306661.  
  4. ^ Baehring JM, Fulbright RK (May 2008). "Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients". J Neurol Neurosurg Psychiatr 79 (5): 535–9. doi:10.1136/jnnp.2007.123737. PMID 17682013.  

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