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Caroverine
Systematic (IUPAC) name
1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one
Identifiers
CAS number 23465-76-1
ATC code A03AX11
PubChem 65709
Chemical data
Formula C 22H27N3O2  
Mol. mass 365.47 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Caroverine (Spasmium, Spadon) is a psychoactive drug and quinoxaline derivative used as a spasmolytic and otoneuroprotective (inner ear protective) agent in some countries.[1] It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.[1] It also has potent antioxidant effects.[1][2]

References

  1. ^ a b c Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H (January 2003). "The antioxidant activity of caroverine". Biochemical Pharmacology 65 (1): 59–65. doi:10.1016/S0006-2952(02)01452-1. PMID 12473379.  
  2. ^ Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV (2003). "Caroverine, a multifunctional drug with antioxidant functions". BioFactors 19 (1-2): 79–85. doi:10.1002/biof.5520190110. PMID 14757980.  
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