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cation channel, sperm associated 1
Identifiers
Symbols CATSPER1; CATSPER; MGC33335; MGC33368
External IDs OMIM606389 MGI2179947 HomoloGene14207 IUPHAR: CatSper1 GeneCards: CATSPER1 Gene
Orthologs
Species Human Mouse
Entrez 117144 225865
Ensembl ENSG00000175294 ENSMUSG00000038498
UniProt Q8NEC5 Q91ZR5
RefSeq (mRNA) NM_053054 NM_139301
RefSeq (protein) NP_444282 NP_647462
Location (UCSC) Chr 11:
65.54 - 65.55 Mb
Chr 19:
5.34 - 5.34 Mb
PubMed search [1] [2]

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene.[1][2][3] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[4]

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.[5]

References

  1. ^ Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMID 11675491.  
  2. ^ Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE (October 2001). "A sperm ion channel required for sperm motility and male fertility". Nature 413 (6856): 603–9. doi:10.1038/35098027. PMID 11595941.  
  3. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.  
  4. ^ "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/IC/FamilyIntroductionForward?familyId=13.  
  5. ^ "Entrez Gene: CatSper1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117144.  

Further reading

  • Li HG, Liao AH, Ding XF, et al. (2006). "The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa.". Asian J. Androl. 8 (3): 301-6. doi:10.1111/j.1745-7262.2006.00132.x. PMID 16625279.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.  
  • Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.". J. Biol. Chem. 281 (31): 22332-41. doi:10.1074/jbc.M511288200. PMID 16740636.  
  • Avenarius MR, Hildebrand MS, Zhang Y, et al. (2009). "Human male infertility caused by mutations in the CATSPER1 channel protein.". Am. J. Hum. Genet. 84 (4): 505-10. doi:10.1016/j.ajhg.2009.03.004. PMID 19344877.  
  • Garbers DL (2001). "Ion channels. Swimming with sperm.". Nature 413 (6856): 579, 581-2. doi:10.1038/35098164. PMID 11595929.  
  • Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa.". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527-31. doi:10.1073/pnas.221454998. PMID 11675491.  
  • Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.". Pharmacol. Rev. 57 (4): 451-4. doi:10.1124/pr.57.4.7. PMID 16382101.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Nikpoor P, Mowla SJ, Movahedin M, et al. (2004). "CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility.". Hum. Reprod. 19 (1): 124-8. PMID 14688170.  
  • Ren D, Navarro B, Perez G, et al. (2001). "A sperm ion channel required for sperm motility and male fertility.". Nature 413 (6856): 603-9. doi:10.1038/35098027. PMID 11595941.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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