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cation channel, sperm associated 2
Identifiers
Symbol CATSPER2
External IDs OMIM607249 MGI2387404 HomoloGene77423 IUPHAR: CatSper2 GeneCards: CATSPER2 Gene
Orthologs
Species Human Mouse
Entrez 117155 212670
Ensembl ENSG00000166762 ENSMUSG00000033486
UniProt Q96P56 Q3UQJ3
RefSeq (mRNA) NM_172095 NM_153075
RefSeq (protein) NM_054020 NP_694715
Location (UCSC) Chr 15:
41.71 - 41.75 Mb
Chr 2:
121.22 - 121.24 Mb
PubMed search [1] [2]

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene.[1][2] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[3]

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.[4]

References

  1. ^ Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMID 11675491.  
  2. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.  
  3. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/IC/FamilyIntroductionForward?familyId=13.  
  4. ^ "Entrez Gene: CatSper2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117155.  

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.". J. Biol. Chem. 281 (31): 22332-41. doi:10.1074/jbc.M511288200. PMID 16740636.  
  • Garbers DL (2001). "Ion channels. Swimming with sperm.". Nature 413 (6856): 579, 581-2. doi:10.1038/35098164. PMID 11595929.  
  • Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa.". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527-31. doi:10.1073/pnas.221454998. PMID 11675491.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.  
  • Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.". Pharmacol. Rev. 57 (4): 451-4. doi:10.1124/pr.57.4.7. PMID 16382101.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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