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Catechol-O-methyl transferase inhibitor: Wikis


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From Wikipedia, the free encyclopedia

A COMT inhibitor is a drug which inhibits the action of catechol-O-methyl transferase. This enzyme is involved in degrading neurotransmitters.

COMT inhibitors are used in the treatment of Parkinson's disease.

An example is entacapone.[1] Another example is tolcapone.[2]

Reference s

  1. ^ Nissinen E, Nissinen H, Larjonmaa H, et al. (September 2005). "The COMT inhibitor, entacapone, reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats". J Neural Transm 112 (9): 1213–21. doi:10.1007/s00702-004-0262-4. PMID 15614425.  
  2. ^ Giakoumaki SG, Roussos P, Bitsios P (June 2008). "Improvement of Prepulse Inhibition and Executive Function by the COMT Inhibitor Tolcapone Depends on COMT Val158Met Polymorphism". Neuropsychopharmacology 33: 3058. doi:10.1038/npp.2008.82. PMID 18536698.  


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