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Cav1.3: Wikis


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Calcium channel, voltage-dependent, L type, alpha 1D subunit

PDB rendering based on 2be6.
Available structures
Symbols CACNA1D; CACH3; CACN4; CACNL1A2; CCHL1A2; Cav1.3
External IDs OMIM114206 MGI88293 HomoloGene578 IUPHAR: Cav1.3 GeneCards: CACNA1D Gene
RNA expression pattern
PBB GE CACNA1D 210108 at tn.png
PBB GE CACNA1D 207998 s at tn.png
More reference expression data
Species Human Mouse
Entrez 776 12289
Ensembl ENSG00000157388 ENSMUSG00000015968
UniProt Q01668 Q99246
RefSeq (mRNA) NM_000720 NM_028981
RefSeq (protein) NP_000711 NP_083257
Location (UCSC) Chr 3:
53.5 - 53.82 Mb
Chr 14:
28.87 - 29.32 Mb
PubMed search [1] [2]

Cav1.3 also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene.[1]


See also


Further reading

  • Williams ME, Feldman DH, McCue AF, et al. (1992). "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.". Neuron 8 (1): 71–84. doi:10.1016/0896-6273(92)90109-Q. PMID 1309651.  
  • Seino S, Chen L, Seino M, et al. (1992). "Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.". Proc. Natl. Acad. Sci. U.S.A. 89 (2): 584–8. doi:10.1073/pnas.89.2.584. PMID 1309948.  
  • Seino S, Yamada Y, Espinosa R, et al. (1992). "Assignment of the gene encoding the alpha 1 subunit of the neuroendocrine/brain-type calcium channel (CACNL1A2) to human chromosome 3, band p14.3.". Genomics 13 (4): 1375–7. doi:10.1016/0888-7543(92)90078-7. PMID 1324226.  
  • Chin HM, Kozak CA, Kim HL, et al. (1992). "A brain L-type calcium channel alpha 1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3.". Genomics 11 (4): 914–9. doi:10.1016/0888-7543(91)90014-6. PMID 1664412.  
  • Mori Y, Friedrich T, Kim MS, et al. (1991). "Primary structure and functional expression from complementary DNA of a brain calcium channel.". Nature 350 (6317): 398–402. doi:10.1038/350398a0. PMID 1849233.  
  • Yamada Y, Masuda K, Li Q, et al. (1995). "The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes.". Genomics 27 (2): 312–9. doi:10.1006/geno.1995.1048. PMID 7557998.  
  • Puro DG, Hwang JJ, Kwon OJ, Chin H (1996). "Characterization of an L-type calcium channel expressed by human retinal Müller (glial) cells.". Brain Res. Mol. Brain Res. 37 (1-2): 41–8. doi:10.1016/0169-328X(96)80478-5. PMID 8738134.  
  • Yang SN, Larsson O, Bränström R, et al. (1999). "Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10164–9. doi:10.1073/pnas.96.18.10164. PMID 10468580.  
  • Bell DC, Butcher AJ, Berrow NS, et al. (2001). "Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents.". J. Neurophysiol. 85 (2): 816–27. PMID 11160515.  
  • Rosenthal R, Thieme H, Strauss O (2001). "Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L-type channels (Ca(v)1.3).". FASEB J. 15 (6): 970–7. doi:10.1096/fj.00-0188com. PMID 11292657.  
  • Davare MA, Avdonin V, Hall DD, et al. (2001). "A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2.". Science 293 (5527): 98–101. doi:10.1126/science.293.5527.98. PMID 11441182.  
  • Namkung Y, Skrypnyk N, Jeong MJ, et al. (2001). "Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation.". J. Clin. Invest. 108 (7): 1015–22. PMID 11581302.  
  • Stokes L, Gordon J, Grafton G (2004). "Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.". J. Biol. Chem. 279 (19): 19566–73. doi:10.1074/jbc.M401481200. PMID 14981074.  
  • Qu Y, Baroudi G, Yue Y, Boutjdir M (2006). "Novel molecular mechanism involving alpha1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia.". Circulation 111 (23): 3034–41. doi:10.1161/CIRCULATIONAHA.104.517326. PMID 15939813.  
  • Baroudi G, Qu Y, Ramadan O, et al. (2006). "Protein kinase C activation inhibits Cav1.3 calcium channel at NH2-terminal serine 81 phosphorylation site.". Am. J. Physiol. Heart Circ. Physiol. 291 (4): H1614–22. doi:10.1152/ajpheart.00095.2006. PMID 16973824.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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