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Cefadroxil: Wikis

  
  

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Cefadroxil
Systematic (IUPAC) name
(6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number 66592-87-8
ATC code J01DB05
PubChem 47964
DrugBank APRD00196
ChemSpider 43629
Chemical data
Formula C 16H17N3O5S 
Mol. mass 363.389 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding plasma protein
Metabolism unknown
Half life 1.5 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Cefadroxil is a broad-spectrum antibiotic effective in Gram-positive and Gram-negative bacterial infections. It is a bactericidal antibiotic. It is marked by pharco B international under the name of Curisafe.

Contents

Brand name

  1. Arocef (Eskayef Bangladesh Limited), Bangladesh
  2. Zadro 500 , India,
  3. Duricef, Pakistan
  4. Alycef (Alkaloid, Inc.), Republic of Macedonia
  5. Duraxil, Hong Kong

General use

Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacteria "Streptococcus pyogenes", otherwise known as strep throat.

Pharmacokinetics

Cefadroxil is almost completely absorbed from the gastrointestinal tract. After doses of 500 mg and 1 g by mouth, peak plasma concentrations of about 16 and 30 micrograms/mL respectively are obtained after 1.5 to 2 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. The plasma half-life of cefadroxil is about 1.5 hours and is prolonged in patients with renal impairment.

Cefadroxil is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk.

More than 90% of a dose of cefadroxil may be excreted unchanged in the urine within 24 hours by glomerular filtration and tubular secretion; peak urinary concentrations of 1.8 mg/mL have been reported after a dose of 500 mg. Cefadroxil is removed by haemodialysis.

Dosage

Cefadroxil is given by mouth, and doses are expressed in terms of the anhydrous substance; 1.04 g of cefadroxil monohydrate is equivalent to about 1 g of anhydrous cefadroxil.

Side effects

The most common side effects of Cefadroxil are diarrhea (which, less commonly, may be bloody), nausea, upset stomach, and vomiting. Other side effects include[1]:

  • Rashes
  • Hives
  • Itching
  • Red, swollen, or blistered skin
  • Unusual bruising or bleeding
  • Sore throat
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Decreased urination
  • Dark urine
  • Vaginal itching, odor, or discharge
  • Fever
  • Chills
  • Joint pain
  • Seizures
  • Cramps
  • Unusual tiredness or weakness
  • Yellowing of the skin or eyes

Dental use

Cefadroxil is used as an antibiotic prophylaxis before dental procedures.

(Always consider Amoxicillin plus Metronidazole as first line of treatment for dental procedures. In Case of penicillin allergy consider "Cefadroxil" for prophylaxis.)

Veterinary use

Can be used for treating infected wounds on animals. Usually in powder form mixed with water has a color and smell similar to Tang. Given orally to animals, amount dependent on their weight and severity of infection.

References








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