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Cefalotin: Wikis


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Systematic (IUPAC) name
(6R,7R)-3-[(acetoxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS number 153-61-7
ATC code J01DB03
PubChem 6024
DrugBank APRD00859
ChemSpider 5802
Chemical data
Formula C 16H16N2O6S2  
Mol. mass 396.44 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability n/a
Protein binding 65 to 80%
Metabolism Hepatic
Half life 30 minutes to 1 hour
Excretion Renal
Therapeutic considerations
Pregnancy cat. A(AU)
Legal status Prescription Only (S4) (AU) POM (UK)
Routes IV
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Cefalotin (INN) (pronounced /ˌsɛfəˈloʊtɨn/) or cephalothin (USAN) (/ˌsɛfəˈloʊθɨn/) is a first-generation cephalosporin antibiotic. It was the first cephalosporin marketed and continues to be widely used. It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is commonly marketed under the trade name Keflin (Lilly).

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