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Cefdinir: Wikis

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Cefdinir
Systematic (IUPAC) name
8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso-
ethenyl]amino-4-ethenyl-7-oxo-2-thia-6-
azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
Identifiers
CAS number 91832-40-5
ATC code J01DD15
PubChem 6915944
DrugBank APRD00644
ChemSpider 5291705
Chemical data
Formula C 14H13N5O5S2  
Mol. mass 395.416 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 16% to 21% (dose-dependent)
Protein binding 60% to 70%
Metabolism Negligible
Half life 1.7 ± 0.6 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat. B(US)
Legal status -only (US)
Routes Oral
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Cefdinir (marketed by Abbott Laboratories under the brand name Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA) in December 1997.

As of 2008, cefdinir was the highest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales of its generic versions alone.[1]

Contents

Mechanism of action

Indications

Therapeutic uses of cefdinir include otitis media, soft tissue infections, and respiratory tract infections, including sinusitis, strep throat, community-acquired pneumonia and acute exacerbations of bronchitis.

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Susceptible organisms

Cefdinir is a bacteriocidal antibiotic. It can be used to treat infections caused by several Gram-negative and Gram-positive bacteria.

Side effects

According to the Omnicef website, side effects include "(...) diarrhea, vaginal infections or inflammation, nausea, headache, and abdominal pain."[2]

Available forms

Omnicef 300 mg

Cefdinir is administered orally. It is available as capsules and a suspension. Dosage, schedule, and duration of therapy varies according to the type of infection.

Cefdinir is available as a generic drug. Glenmark Pharmaceuticals launched a generic version of cefdinir called Kefnir in Malaysia in 2009). In the MENA region, it is marketed by Hikma Pharmaceuticals PLC under the brand name Omnicef.

"Blood" in the Stool

The pediatric version of Omnicef can bind to iron in the digestive tract. In rare cases, this creates a discoloration of the stool to a rust or red color. Some patients may interpret this as blood in the stool, although in reality blood appears dark brown or black in the stool. A doctor's office can perform a simple stool guaiac test on the stool to confirm that it does not have blood. If you simply wait one hour, the red color will remain red, (while real blood will turn black).

On the other hand, if the reddish stool is accompanied by abdominal pain, weight loss, diarrhea, etc., it could be a C. difficile (clostridium difficile) infection caused by the antibiotic. This infection can occur as a result of taking an antibiotic. Talk to your pediatrician immediately to see if you should stop using the antibiotic.

References

  1. ^ "2008 Top 200 generic drugs by retail dollars" PDF (399.4 KB). Drug Topics (May 26, 2009). Retrieved on July 24, 2009.
  2. ^ "Omnicef capsules Patient Information". Abbott Laboratories. February 2004. http://www.rxabbott.com/pdf/omnicef_capsules_patient_friendly.pdf. Retrieved 2006-11-24.  

[1] U.S. Prescribing Information from Omnicef.com


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