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Cefixime: Wikis


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Systematic (IUPAC) name
1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS number 79350-37-1
ATC code J01DD08
PubChem 5362065
DrugBank APRD00583
ChemSpider 4514923
Chemical data
Formula C 16H15N5O7S2  
Mol. mass 453.452 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 40% to 50%
Protein binding Approximately 60%
Metabolism  ?
Half life Variable
Average 3 to 4 hours
Excretion Renal and biliary
Therapeutic considerations
Pregnancy cat. B
Legal status
Routes Oral
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Cefixime is an oral third generation cephalosporin antibiotic. It is used to treat gonorrhea,[1] tonsilitis,[2] and pharyngitis.[2]

The usual dose is 400mg in two divided doses for up to 5-7 days.

It was sold under the trade name Suprax in the USA, until 2003 when it was taken off the market by drug manufacturer Wyeth after its patent expired. The oral suspension form of "Suprax" was re-launched by Lupin in the USA. Cefixime is still available in Canada. In India it is available under brand names, such as, ZEEFIX (Agio Pharmaceuticals Ltd.);CEFIGARD50DT,100DT,200DT,Dry syrup(Vanguard therapetics Pvt Ltd), Ceftas-200 (Intas Pharmaceuticals); ZiFi CV-200 (FDC Limited) Alfi (Alkem Laboratories). In Bangladesh it is manufactured by several manufacturers. Delta Pharma Limited is one of them with the brand name Ofex [3]. Others are Cap.Cef3(200mg) [Square Pharmaceuticals]; Cap. 3-C (200mg) [Edruc Pharmaceuticals] etc. It is a widely used antibiotic in Bangladesh. In Pakistan it is available under brand names such as Cebosh and Secure (Wilshire Lab. Pvt. Ltd.)


In India, it has been released with brand name Keflin-200, Taxim-O, Altacef, Curocef-200, Topcef, cefspan, Mahacef (by Mankind Pharma), ZIFI-200 (by FDC Ltd)

  1. ^ McMillan A, Young H. (2007). "The treatment of pharyngeal gonorrhoea with a single oral dose of cefixime". Int J STD AIDS 18 (4): 253–4. doi:10.1258/095646207780658971. PMID 17509176.  
  2. ^ a b Adam D, Hostalek U, Tröster K. (1995). "5-day cefixime therapy for bacterial pharyngitis and/or tonsillitis: comparison with 10-day penicillin V therapy". Infection 23 (Suppl 2): S83–6. doi:10.1007/BF01742990. PMID 8537138.  
  3. ^

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