The Full Wiki

More info on Cefmetazole

Cefmetazole: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Cefmetazole
Systematic (IUPAC) name
(6R,7S)-7-{[2-(cyanomethylsulfanyl)acetyl]amino}-
7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-
8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number 56796-20-4
ATC code J01DC09
PubChem 42008
ChemSpider 38311
Chemical data
Formula C 15H17N7O5S3  
Mol. mass 471.538 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
 Yes check.svgY(what is this?)  (verify)

Cefmetazole is a cephalosporin antibiotic, usually grouped with the second-generation cephalosporins.

Adverse effects

The chemical structure of cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.[1]

References

  1. ^ Stork CM (2006). "Antibiotics, antifungals, and antivirals". in Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA (eds.). Goldfrank's toxicologic emergencies. New York: McGraw-Hill. pp. 847. ISBN 0-07-143763-0. http://books.google.com/books?id=cvJuLqBxGUcC&pg=PA847. Retrieved 2009-07-03.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message