The Full Wiki

More info on Cefoxitin

Cefoxitin: Wikis

  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Cefoxitin
Systematic (IUPAC) name
(6S,7R)-4-(carbamoyloxymethyl)-7-methoxy-
8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-
1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number 35607-66-0
ATC code J01DC01
PubChem 37194
Chemical data
Formula C 16H17N3O7S2  
Mol. mass 427.454 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism minimal
Half life 41-59 min
Excretion 85% urine
Therapeutic considerations
Pregnancy cat. B
Legal status
Routes IV

Cefoxitin is a cephamycin antibiotic developed by Merck & Co., Inc., often grouped with the second−generation cephalosporins. It is also known as Mefoxin.

Microbiology

Cefoxitin acts by interfering with cell wall synthesis. Its activity spectrum includes a broad range of gram-negative and gram-positive bacteria including anaerobes. It is inactive in vitro to most strains of Pseudomonas aeruginosa and enterococci and many strains of Enterobacter cloacae. Staphylococci resistant to methicillin/oxacillin should be considered resistant to cefoxitin. [1] Cefoxitin, along with some other antibiotics (for example,imipenem), considered to be strong beta-lactamase inducer.

References

  1. ^ Mefoxin Official FDA information at Drugs.com







Got something to say? Make a comment.
Your name
Your email address
Message