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Cefoxitin: Wikis


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Systematic (IUPAC) name
1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS number 35607-66-0
ATC code J01DC01
PubChem 37194
Chemical data
Formula C 16H17N3O7S2  
Mol. mass 427.454 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism minimal
Half life 41-59 min
Excretion 85% urine
Therapeutic considerations
Pregnancy cat. B
Legal status
Routes IV

Cefoxitin is a cephamycin antibiotic developed by Merck & Co., Inc., often grouped with the second−generation cephalosporins. It is also known as Mefoxin.


Cefoxitin acts by interfering with cell wall synthesis. Its activity spectrum includes a broad range of gram-negative and gram-positive bacteria including anaerobes. It is inactive in vitro to most strains of Pseudomonas aeruginosa and enterococci and many strains of Enterobacter cloacae. Staphylococci resistant to methicillin/oxacillin should be considered resistant to cefoxitin. [1] Cefoxitin, along with some other antibiotics (for example,imipenem), considered to be strong beta-lactamase inducer.


  1. ^ Mefoxin Official FDA information at

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