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Cefpodoxime: Wikis


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Systematic (IUPAC) name
carboxylic acid
CAS number 82619-04-3
ATC code J01DD13
PubChem 6335986
ChemSpider 4891496
Chemical data
Formula C 15H17N5O6S2  
Mol. mass 427.458 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 50%
Protein binding 21% to 29%
Metabolism Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver
Half life 2 hours
Excretion Renal, unchanged
Therapeutic considerations
Pregnancy cat. B1(AU) B(US)
Legal status -only (US)
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Cefpodoxime (marketed as the prodrug cefpodoxime proxetil by Pharmacia & Upjohn under the trade name Vantin and under the name Orelox by Sanofi-Aventis), is an oral third generation cephalosporin. It is active against most Gram positive and Gram negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.

Pfizer, the parent company of Pharmacia & Upjohn, markets Cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day.

In India, it is sold for children under the trade name of Zefira (Agio Pharmaceuticals Ltd), Cepotuf (Vanguard Therapeutics Pvt Ltd), Pecef (Dr Reddy's) in 50mg & 100mg DT & DS forms (FGP) and for adults as C-Doxim 200, 100DT, 50 DS (Neomed) and Doxicef 200 (Lupin) in 200mg.

In Nigeria its marketed under brand name of Switch 200mg by Alkem Laboratories..

Structural formula of cefpodoxime proxetil

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