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Meclofenoxate
Systematic (IUPAC) name
2-dimethylaminoethyl (4-chlorophenoxy)acetate
Identifiers
CAS number 51-68-3
ATC code N06BX01
PubChem 4039
Chemical data
Formula C 12H16ClNO3  
Mol. mass 257.713
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Centrophenoxine (also called Meclofenoxate, and formerly sold under the brand name Lucidril) is a drug used to treat the symptoms of senile dementia and Alzheimer's Disease. It is a compound of two biochemicals: dimethylaminoethanol (DMAE) and parachlorophenoxyacetate (pCPA). DMAE is a natural substance, found especially in fish, and also produced in the human brain. pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.

Like DMAE, it is a precursor to the neurotransmitter acetylcholine and may increase levels of this chemical in the CNS. It also increases cellular membrane phospholipids which is considered by some to be an important antiaging effect. It has been clinically shown to improve memory, have a mentally stimulating effect, and improve general cognition.

It is also used off-label as a nootropic, often combined with a racetam drug such as piracetam. A typical nootropic dose is 250-3,000 mg taken in 1 or more doses.

Side effects and contraindications

Centrophenoxine is generally considered safe. However possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid Centrophenoxine.[1] Large doses may cause tight jaw clenching.

References

  1. ^ Centrophenoxine Page @ The American Academy of Anti-Aging Medicine

External links








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