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Cevimeline: Wikis

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Cevimeline
Systematic (IUPAC) name
2-methyspiro (1,3- oxathiolane- 5,3) quinuclidine
Identifiers
CAS number 107233-08-9
ATC code N07AX03
PubChem 83898
DrugBank APRD00224
ChemSpider 75707
Chemical data
Formula C 10H17NOS 
Mol. mass 489.565 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding < 20%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat. C
Legal status Rx only
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Cevimeline is a parasympathomimetic and muscarinic agonist,[1] with particular effect on M3 receptors. It is used in the treatment of dry mouth associated with Sjögren's syndrome.

Contents

Mechanism of action

By activating the M3 receptors of the parasympathetic nervous system, cevimeline stimulates secretion by the salivary glands, thereby alleviating dry mouth.

Side effects

Known side effects include nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, and difficulty sleeping. [2]

References

External links

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