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Charles Yanofsky

Born April 17, 1925 (1925-04-17) (age 84)
New York
Nationality United States
Fields Genetics
Institutions Stanford University
Notable awards National Medal of Science (2003)
Louisa Gross Horwitz Prize(1976)

Charles Yanofsky (born April 17, 1925) is a leading American geneticist.

Born in New York, Yanofsky studied at the City College of New York and at Yale University.

In 1964, Yanofsky and colleagues established that gene sequences and protein sequences are colinear: changes in DNA sequence can produce changes in protein sequence at corresponding positions. His work has revealed how controlled alterations in RNA structure allow RNA to serve as a regulatory molecule in both bacterial and animal cells.

Yanofsky was co-recipient of the Louisa Gross Horwitz Prize from Columbia University in 1976 with Seymour Benzer.Yanofsky was elected a foreign member of the Royal Society in 1985 and was one of the recipients of the 2003 National Medal of Science awards.

Charles Yanofsky is now the Morris Herzstein Professor of Biology and Molecular Biology (Emeritus) at Stanford University.


  • Yanofsky, Charles (2007), "RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria.", RNA 13 (8): 1141–54, 2007 Aug, doi:10.1261/rna.620507, PMID 17601995  
  • Yanofsky, Charles (2005), "The favorable features of tryptophan synthase for proving Beadle and Tatum's one gene-one enzyme hypothesis.", Genetics 169 (2): 511–6, 2005 Feb, PMID 15731515  
  • Yanofsky, Charles (2004), "The different roles of tryptophan transfer RNA in regulating trp operon expression in E. coli versus B. subtilis.", Trends Genet. 20 (8): 367–74, 2004 Aug, doi:10.1016/j.tig.2004.06.007, PMID 15262409  
  • Yanofsky, C (2000), "Transcription attenuation: once viewed as a novel regulatory strategy.", J. Bacteriol. 182 (1): 1–8, 2000 Jan, doi:10.1128/JB.182.1.1-8.2000, PMID 10613855  
  • Yanofsky, C; Konan, K V; Sarsero, J P (1996), "Some novel transcription attenuation mechanisms used by bacteria.", Biochimie 78 (11-12): 1017–24, doi:10.1016/S0300-9084(97)86725-9, PMID 9150880  
  • Yanofsky, C (1988), "Transcription attenuation.", J. Biol. Chem. 263 (2): 609–12, 1988 Jan 15, PMID 3275656  
  • Yanofsky, C; Platt, T; Crawford, I P; Nichols, B P (1981), "The complete nucleotide sequence of the tryptophan operon of Escherichia coli.", Nucleic Acids Res. 9 (24): 6647–68, 1981 Dec 21, doi:10.1093/nar/9.24.6647, PMID 7038627  
  • Yanofsky, C (1981), "Attenuation in the control of expression of bacterial operons.", Nature 289 (5800): 751–8, 1981 Feb 26, doi:10.1038/289751a0, PMID 7007895  
  • Yanofsky, C (1971), "Tryptophan biosynthesis in Escherichia coli. Genetic determination of the proteins involved.", JAMA 218 (7): 1026–35, 1971 Nov 15, doi:10.1001/jama.218.7.1026, PMID 4940311  
  • Yanofsky, C (1967), "Gene structure and protein structure.", Harvey Lect. 61: 145–68, PMID 5338072  

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