Chatterbox may refer to:

In music

• "Chatterbox", a song by composer Jerome (Jerry) Brainin for the musical film That’s Right You’re Wrong (1939)
• Chatterbox (album), a 1990 album by Toadies frontman Todd Lewis and guitarist Darrel Herbert
• Chatterbox Records, an Australian based record label

In print

• Chatterbox, a political column written by Timothy Noah and featured on Slate, a magazine
• Chatterbox, a halfpenny weekly paper for older children founded in 1866 by John Erskine Clarke, which ran for some 90 years in the UK and 60 in the USA

In computers

• Chatterbot or chatterbox, a computer bot which attempts to maintain a conversation with a person
• A shoutbox, a website feature that allows people to quickly leave messages on said website

In games

• Chatterbox FM, a fictional talk radio station in the computer and video game Grand Theft Auto III, as well as Grand Theft Auto: Liberty City Stories

In movies and television

• Chatterbox, a 1936 film starring Anne Shirley, Phillips Holmes and Edward Ellis. Features a brief screen appearance (early in her career) by the young Lucille Ball. Directed by George Nichols, Jr. B&W, 69 minutes.
• Chatterbox, a 1943 movie directed by Joseph Santley starring Joe E. Brown and Judy Canova
• Chatterbox, a 1977 movie starring Candice Rialson as a woman with a talking vagina
• Chatterbox, a puppet on Australian TV series Hi-5

In People

• Mr. Chatterbox, a Mr. Men character.
• Little Miss Chatterbox, a Little Miss character.
• [chatterbox], a person that talks a lot.

Miscellaneous

• Cootie catcher, an origami that is also called a "chatterbox".
• Chatterbox, a member of the fictional disaster squad Ro-Busters from the pages of early issues of StarLord and 2000ad.''