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Chloride potassium symporter 5: Wikis

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Solute carrier family 12, (potassium-chloride transporter) member 5
Identifiers
Symbols SLC12A5; KCC2; KIAA1176
External IDs OMIM606726 MGI1862037 HomoloGene10665 GeneCards: SLC12A5 Gene
RNA expression pattern
PBB GE SLC12A5 210040 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57468 57138
Ensembl ENSG00000124140 ENSMUSG00000017740
UniProt Q9H2X9 Q3UHQ2
RefSeq (mRNA) NM_020708 NM_020333
RefSeq (protein) NP_065759 NP_065066
Location (UCSC) Chr 20:
44.09 - 44.12 Mb
Chr 2:
164.66 - 164.69 Mb
PubMed search [1] [2]

Potassium-chloride transporter member 5 also known as SLC12A5 is a type of chloride potassium symporter which in humans is encoded by the SLC12A5 gene.[1]

Contents

Function

This potassium-chloride transporter is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons.[1]

See also

References

External links

Further reading

  • Hebert SC, Mount DB, Gamba G (2004). "Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.". Pflugers Arch. 447 (5): 580–93. doi:10.1007/s00424-003-1066-3. PMID 12739168.  
  • Rivera C, Voipio J, Kaila K (2005). "Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII.". J. Physiol. (Lond.) 562 (Pt 1): 27–36. doi:10.1113/jphysiol.2004.077495. PMID 15528236.  
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.  
  • Hübner CA, Stein V, Hermans-Borgmeyer I, et al. (2001). "Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.". Neuron 30 (2): 515–24. doi:10.1016/S0896-6273(01)00297-5. PMID 11395011.  
  • Sallinen R, Tornberg J, Putkiranta M, et al. (2001). "Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K(+)-Cl(-) cotransporter (KCC2) defines a new region of conserved homology.". Cytogenet. Cell Genet. 94 (1-2): 67–70. doi:10.1159/000048785. PMID 11701957.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Song L, Mercado A, Vázquez N, et al. (2002). "Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.". Brain Res. Mol. Brain Res. 103 (1-2): 91–105. doi:10.1016/S0169-328X(02)00190-0. PMID 12106695.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Lee H, Chen CX, Liu YJ, et al. (2005). "KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses.". Eur. J. Neurosci. 21 (9): 2593–9. doi:10.1111/j.1460-9568.2005.04084.x. PMID 15932617.  
  • Mercado A, Broumand V, Zandi-Nejad K, et al. (2006). "A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport.". J. Biol. Chem. 281 (2): 1016–26. doi:10.1074/jbc.M509972200. PMID 16291749.  
  • Vanhatalo S, Palva JM, Andersson S, et al. (2006). "Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex.". Eur. J. Neurosci. 22 (11): 2799–804. doi:10.1111/j.1460-9568.2005.04459.x. PMID 16324114.  
  • Lee HH, Walker JA, Williams JR, et al. (2007). "Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2.". J. Biol. Chem. 282 (41): 29777–84. doi:10.1074/jbc.M705053200. PMID 17693402.  
  • Uvarov P, Ludwig A, Markkanen M, et al. (2007). "A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.". J. Biol. Chem. 282 (42): 30570–6. doi:10.1074/jbc.M705095200. PMID 17715129.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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