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Chloride potassium symporter 5: Wikis


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Solute carrier family 12, (potassium-chloride transporter) member 5
Symbols SLC12A5; KCC2; KIAA1176
External IDs OMIM606726 MGI1862037 HomoloGene10665 GeneCards: SLC12A5 Gene
RNA expression pattern
PBB GE SLC12A5 210040 at tn.png
More reference expression data
Species Human Mouse
Entrez 57468 57138
Ensembl ENSG00000124140 ENSMUSG00000017740
UniProt Q9H2X9 Q3UHQ2
RefSeq (mRNA) NM_020708 NM_020333
RefSeq (protein) NP_065759 NP_065066
Location (UCSC) Chr 20:
44.09 - 44.12 Mb
Chr 2:
164.66 - 164.69 Mb
PubMed search [1] [2]

Potassium-chloride transporter member 5 also known as SLC12A5 is a type of chloride potassium symporter which in humans is encoded by the SLC12A5 gene.[1]



This potassium-chloride transporter is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons.[1]

See also


External links

Further reading

  • Hebert SC, Mount DB, Gamba G (2004). "Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.". Pflugers Arch. 447 (5): 580–93. doi:10.1007/s00424-003-1066-3. PMID 12739168.  
  • Rivera C, Voipio J, Kaila K (2005). "Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII.". J. Physiol. (Lond.) 562 (Pt 1): 27–36. doi:10.1113/jphysiol.2004.077495. PMID 15528236.  
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.  
  • Hübner CA, Stein V, Hermans-Borgmeyer I, et al. (2001). "Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.". Neuron 30 (2): 515–24. doi:10.1016/S0896-6273(01)00297-5. PMID 11395011.  
  • Sallinen R, Tornberg J, Putkiranta M, et al. (2001). "Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K(+)-Cl(-) cotransporter (KCC2) defines a new region of conserved homology.". Cytogenet. Cell Genet. 94 (1-2): 67–70. doi:10.1159/000048785. PMID 11701957.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Song L, Mercado A, Vázquez N, et al. (2002). "Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.". Brain Res. Mol. Brain Res. 103 (1-2): 91–105. doi:10.1016/S0169-328X(02)00190-0. PMID 12106695.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Lee H, Chen CX, Liu YJ, et al. (2005). "KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses.". Eur. J. Neurosci. 21 (9): 2593–9. doi:10.1111/j.1460-9568.2005.04084.x. PMID 15932617.  
  • Mercado A, Broumand V, Zandi-Nejad K, et al. (2006). "A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport.". J. Biol. Chem. 281 (2): 1016–26. doi:10.1074/jbc.M509972200. PMID 16291749.  
  • Vanhatalo S, Palva JM, Andersson S, et al. (2006). "Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex.". Eur. J. Neurosci. 22 (11): 2799–804. doi:10.1111/j.1460-9568.2005.04459.x. PMID 16324114.  
  • Lee HH, Walker JA, Williams JR, et al. (2007). "Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2.". J. Biol. Chem. 282 (41): 29777–84. doi:10.1074/jbc.M705053200. PMID 17693402.  
  • Uvarov P, Ludwig A, Markkanen M, et al. (2007). "A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.". J. Biol. Chem. 282 (42): 30570–6. doi:10.1074/jbc.M705095200. PMID 17715129.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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