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Chlorisondamine: Wikis

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Chlorisondamine
Systematic (IUPAC) name
trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-isoindolin-2-ium-2-yl)ethyl]ammonium dichloride
Identifiers
CAS number 7701-62-4
ATC code  ?
PubChem 6243
ChemSpider 6007
Chemical data
Formula C14H20Cl6N2
Mol. mass 429.04 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Chlorisondamine is a nicotinic acetylcholine receptor antagonist that produces both neuronal and ganglionic blockade.

Chlorisondamine has been shown to form noncovalent complexes with various biomolecules including sphingomyelin and other associated glycolipids.[1][2][3]

References

  1. ^ Woods, A. S.; Moyer, S. C.; Wang, H. Y. J.; Wise, R. A., Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor. Journal of Proteome Research 2003, 2 (2), 207-212.
  2. ^ Jackson, S. N.; Wang, H. Y. J.; Woods, A. S., Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS. Journal of the American Society for Mass Spectrometry 2005, 16 (2), 133-138.
  3. ^ Woods, A. S.; Ugarov, M.; Egan, T.; Koomen, J.; Gillig, K. J.; Fuhrer, K.; Gonin, M.; Schultz, J. A., Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS. Analytical Chemistry 2004, 76 (8), 2187-2195.
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