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Chlornaltrexamine: Wikis

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Chlornaltrexamine
Chlornaltrexamine.png
IUPAC name
Other names alpha-chlornaltrexamine
Identifiers
CAS number 67025-94-9
PubChem 5486190
SMILES
Properties
Molecular formula C24H32Cl2N2O3
Molar mass 467.43 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Chlornaltrexamine is an irreversible mixed agonist-antagonist for μ-opioid receptors, which forms a covalent bond to the active site. It is 22 times more potent than morphine. Its alkylating group is a bis(chloroalkyl)amino-residue similar to that of the nitrogen mustards.[1]

See also

References

  1. ^ L. M. Sayre; A. E. Takemori; P. S. Portoghese (1983). Journal of Medicinal Chemistry 26 (4): 503. doi:10.1021/jm00358a009.  
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