The Full Wiki



More info on Chlornaphazine

Chlornaphazine: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

Updated live from Wikipedia, last check: May 31, 2012 19:35 UTC (54 seconds ago)

From Wikipedia, the free encyclopedia

Chlornaphazine
Chlornaphazine.png
IUPAC name
Other names Chlornapazine; 2-Naphthylbis(chloroethyl)amine
Identifiers
CAS number 494-03-1
PubChem 10307
SMILES
Properties
Molecular formula C14H15Cl2N
Molar mass 268.18 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Chlornaphazine, a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of polycythemia and Hodgkin's disease.[1] However, a high incidence of bladder cancers in patients receiving treatment with chlornaphthazine led to use of the drug being discontinued.[2]

The International Agency for Research on Cancer has listed chlornaphazine as a human carcinogen.[3]

References

  1. ^ Videbaek, A.; Kaae, S. (1954). "2-Naphthylbis(chloroethyl)amine in the treatment of malignant diseases, particularly Hodgkin's disease". Acta Medica Scandinavica 149 (5): 361–368. PMID 13180246.  
  2. ^ Benedicte Laursen (1970). "Cancer of the Bladder in Patients Treated with Chlornaphazine". Br Med J. 3 (5724): 684–685. doi:10.1136/bmj.3.5724.684. PMID 5470116.  
  3. ^ N,N-Bis(2-Chloroethyl)-2-Naphthylamine (Chlornaphazine), International Agency for Research on Cancer







Got something to say? Make a comment.
Your name
Your email address
Message
Please enter the solution to case below
5-2=