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Chlorzoxazone: Wikis

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Chlorzoxazone
Systematic (IUPAC) name
5-chloro-3H-benzooxazol-2-one
Identifiers
CAS number 95-25-0
ATC code M03BB03
PubChem 2733
DrugBank APRD00308
ChemSpider 2632
Chemical data
Formula C 7H4ClNO2  
Mol. mass 169.565 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability well absorbed
Protein binding 13–18%
Metabolism hepatic
Half life 1.1 hr
Excretion urine (<1%)
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes oral
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Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold as Muscol or Parafon Forte, a combination of chlorzoxazone and acetaminophen. Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction. Used with acetaminophen it has added risk of hepatoxicity, which is why the combination is not recommended.

External links

  • Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF. (2006). "Chlorzoxazone inhibit contraction of rat thoracic aorta.". Eur J Pharmacol 545: 161. doi:10.1016/j.ejphar.2006.06.063. PMID 16859676.  
  • Park J, Kim K, Park P, Ha J (2006). "Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe.". J Clin Pharmacol 46 (1): 109–14. doi:10.1177/0091270005282635. PMID 16397290.  
  • Wan J, Ernstgård L, Song B, Shoaf S (2006). "Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats.". J Pharm Pharmacol 58 (1): 51–61. doi:10.1211/jpp.58.1.0007. PMID 16393464.  
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