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Cholesterol 7 alpha-hydroxylase: Wikis

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cytochrome P450, family 7, subfamily A, polypeptide 1
Identifiers
Symbol CYP7A1
Alt. symbols CYP7
Entrez 1581
HUGO 2651
OMIM 118455
RefSeq NM_000780
UniProt P22680
Other data
EC number 1.14.13.17
Locus Chr. 8 q11-q12

Cholesterol 7 alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme in the synthesis of bile acid from cholesterol, catalyzing the formation of 7-alpha-hydroxycholesterol. CYP7A1 is a cytochrome P450 heme enzyme that oxidizes cholesterol using molecular oxygen.

It is downregulated by Sterol regulatory element binding proteins (SREBP) when plasma cholesterol levels are low. It is upregulated by the nuclear receptor LXR (liver X receptor) when cholesterol (specifically - oxysterol) levels are high.[1] The effect of this upregulation is to increase the production of bile acids and reduce the level of cholesterol in hepatocytes.

References

  1. ^ Chawla A, Saez E, Evans RM (2000). "Don't know much bile-ology". Cell 103: 1–4. doi:10.1016/S0092-8674(00)00097-0.  

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