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More info on Cholesterylester transfer protein

Cholesterylester transfer protein: Wikis

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Cholesteryl ester transfer protein, plasma

PDB rendering based on 2obd.
Available structures
2obd
Identifiers
Symbols CETP;
External IDs OMIM118470 HomoloGene47904 GeneCards: CETP Gene
RNA expression pattern
PBB GE CETP 206210 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1071 n/a
Ensembl ENSG00000087237 n/a
UniProt P11597 n/a
RefSeq (mRNA) NM_000078 n/a
RefSeq (protein) NP_000069 n/a
Location (UCSC) Chr 16:
55.55 - 55.58 Mb
n/a
PubMed search [1] n/a

Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a homoexchange, trading a triglyceride for a triglyceride or a cholesteryl ester for a cholesteryl ester.

Contents

Genetics

The CETP gene is located on the sixteenth chromosome (16q21).

Role in disease

Rare mutations leading to increased function of CETP have been linked to accelerated atherosclerosis.[1] In contrast, a polymorphism (I405V) of the CETP gene leading to lower serum levels has also been linked to exceptional longevity.[2] However, this mutation also increases the prevalence of coronary heart disease in patients with hypertriglyceridemia.[3] The D442G mutation, which lowers CETP levels and increases HDL levels also increases coronary heart disease.[1]

Elaidic acid, a major component of trans fat, increases CETP activity.[4]

Pharmacology

As HDL can alleviate atherosclerosis and other cardiovascular diseases, and certain disease states such as the metabolic syndrome feature low HDL, pharmacological inhibition of CETP is being studied as a method of improving HDL levels.[5] To be specific, in a 2004 study, the small molecular agent torcetrapib was shown to increase HDL levels, alone and with a statin, and lower LDL when co-administered with a statin.[6] Studies into cardiovascular endpoints, however, were largely disappointing. While they confirmed the change in lipid levels, most reported an increase in blood pressure, no change in atherosclerosis,[7][8] and, in a trial of a combination of torcetrapib and atorvastatin, an increase in cardiovascular events and mortality.[9]

A compound related to torcetrapib, with the investigative name JTT-705/R1658, is also being studied.[10] It increases HDL levels by 30%, as compared to 60% by torcetrapib.[11] Another CETP inhibitor under development is Merck's MK-0859 anacetrapib, which in initial studies is not shown to increase blood pressure.[12]

References

  1. ^ a b Zhong S, Sharp DS, Grove JS, Bruce C, Yano K, Curb JD, Tall AR (June 1996). "Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels". J Clin Invest 97 (12): 2917–23. doi:10.1172/JCI118751. ISSN 0021-9738. PMID 8675707. PMC 507389. http://www.jci.org/cgi/content/full/97/12/2917.  
  2. ^ Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR (October 2003). "Unique lipoprotein phenotype and genotype associated with exceptional longevity". JAMA 290 (15): 2030–40. doi:10.1001/jama.290.15.2030. ISSN 0098-7484. PMID 14559957. http://jama.ama-assn.org/cgi/content/full/290/15/2030.  
  3. ^ Bruce C, Sharp DS, Tall AR (1 May 1998). "Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia". J Lipid Res 39 (5): 1071–8. ISSN 0022-2275. PMID 9610775. http://www.jlr.org/cgi/content/full/39/5/1071.  
  4. ^ Abbey M, Nestel PJ (March 1994). "Plasma cholesteryl ester transfer protein activity is increased when trans-elaidic acid is substituted for cis-oleic acid in the diet". Atherosclerosis 106 (1): 99–107. doi:10.1016/0021-9150(94)90086-8. ISSN 0021-9150. PMID 8018112.  
  5. ^ Barter PJ, Brewer HB Jr, Chapman MJ, Hennekens CH, Rader DJ, Tall AR (February 2003). "Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis". Arterioscler Thromb Vasc Biol 23 (2): 160–7. doi:10.1161/01.ATV.0000054658.91146.64. ISSN 1079-5642. PMID 12588754. http://atvb.ahajournals.org/cgi/content/full/23/2/160.  
  6. ^ Brousseau ME, Schaefer EJ, Wolfe ML, Bloedon LT, Digenio AG, Clark RW, Mancuso JP, Rader DJ (April 2004). "Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol". N Engl J Med 350 (15): 1505–15. doi:10.1056/NEJMoa031766. ISSN 0028-4793. PMID 15071125. http://content.nejm.org/cgi/content/full/350/15/1505.  
  7. ^ Nissen Se, Tardif JC; Investigators, Illustrate (March 2007). "Effect of torcetrapib on the progression of coronary atherosclerosis". N Engl J Med 356 (13): 1304–16. doi:10.1056/NEJMoa070635. ISSN 0028-4793. PMID 17387129. http://content.nejm.org/cgi/content/full/356/13/1304.  
  8. ^ Kastelein Jj, van Leuven SI; Investigators, Radiance 1. (April 2007). "Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia" (abstract). N Engl J Med 356 (16): 1620–30. doi:10.1056/NEJMoa071359. ISSN 0028-4793. PMID 17387131. http://content.nejm.org/cgi/content/abstract/356/16/1620.  
  9. ^ U.S. Food and Drug Administration (2006-12-03). "Pfizer Stops All Torcetrapib Clinical Trials in Interest of Patient Safety". Press release. http://www.fda.gov/bbs/topics/news/2006/new01514.html.  
  10. ^ El Harchaoui K, van der Steeg WA, Stroes ES, Kastelein JJ (August 2007). "The role of CETP inhibition in dyslipidemia". Curr Atheroscler Rep 9 (2): 125–33. doi:10.1007/s11883-007-0008-5. ISSN 1523-3804. PMID 17877921.  
  11. ^ de Grooth GJ, Kuivenhoven JA, Stalenhoef AF, de Graaf J, Zwinderman AH, Posma JL, van Tol A, Kastelein JJ (May 2002). "Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study". Circulation 105 (18): 2159–65. doi:10.1161/01.CIR.0000015857.31889.7B. ISSN 0009-7322. PMID 11994249. http://circ.ahajournals.org/cgi/content/full/circulationaha;105/18/2159.  
  12. ^ Reuters (2007-10-04). "Merck announces its investigational CETP-Inhibitor, MK-0859, produced positive effects on lipids with no observed blood pressure changes". Reuters, Inc.. http://www.reuters.com/article/inPlayBriefing/idUSIN20071004163052MRK20071004. Retrieved 2007-11-04.  

Further reading

External links


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