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Cinnarizine
Systematic (IUPAC) name
1-benzhydryl-4-cinnamyl-piperazine
Identifiers
CAS number 298-57-7
ATC code N07CA02
PubChem 2761
DrugBank APRD00332
Chemical data
Formula C 26H28N2  
Mol. mass 368.514 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 3..4h
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral

Cinnarizine (Stugeron, Stunarone) is an antihistamine which is mainly used for the control of nausea and vomiting due to motion sickness. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955. It is not available in the United States or Canada.

It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception.

Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. It is also effectively combined with other nootropics, primarily Piracetam; in such combination each drug potentiate the other in boosting brain oxygen supply.

Cinnarizine can be used in scuba divers without an increased risk of central nervous system oxygen toxicity.[1]

Cinnarizine can cause drowsiness and blurred vision. It is important that users make sure their reactions are normal before driving, operating machinery, or doing any other jobs which could be dangerous if they are not fully alert or able to see well.

References

  1. ^ Arieli R, Shupak A, Shachal B, Shenedrey A, Ertracht O, Rashkovan G (1999). "Effect of the anti-motion-sickness medication cinnarizine on central nervous system oxygen toxicity". Undersea and Hyperbaric Medicine 26 (2): 105–9. PMID 10372430. http://archive.rubicon-foundation.org/2307. Retrieved 2009-03-30.  
  • Barrett RJ, Zolov B (December 1960). "A clinical evaluation of cinnarizine (Mitronal) in various allergic disorders". J Maine Med Assoc 51: 454–7. PMID 13687289.  
  • Towse G (September 1980). "Cinnarizine--a labyrinthine sedative". J Laryngol Otol 94 (9): 1009–15. doi:10.1017/S0022215100089787. PMID 7000939.  







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