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Cirazoline
Cirazoline.png
IUPAC name
Identifiers
CAS number 59939-16-1
PubChem 2765
MeSH cirazoline
SMILES
Properties
Molecular formula C13H16N2O
Molar mass 216.279
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cirazoline is a nonselective agonist of the alpha-1 adrenergic receptor (α1-AR), and an antagonist to the alpha-2 adrenergic receptor[1]. It is believed that this combination of properties could make cirazoline an effective effective vasoconstricting agent[1].

Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of alpha 1-adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain[2].

References

  1. ^ a b "Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist". J Pharmacol Exp Ther. 222: 29–36. 1982.  
  2. ^ "Effects on ingestive behavior in rats of the alpha 1-adrenoceptor agonist cirazoline". Eur J Pharmacol. 210 (1): 11–16. Jan. 1992.  
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