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Cissus quadrangularis
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Rosids
Order: Vitales
Family: Vitaceae
Genus: Cissus
Species: C. quadrangularis
Binomial name
Cissus quadrangularis

Cissus quadrangula
Vitis quadrangularis

Cissus quadrangularis is a perennial plant of the grape family. It is commonly known as Veldt Grape or Devil's Backbone.



It is probably native to India or Sri Lanka, but is also found in Africa, Arabia, and Southeast Asia. It has been imported to Brazil and the southern United States.


Cissus quadrangularis reaches a height of 1.5 m and has quadrangular-sectioned branches with internodes 8 to 10 cm long and 1.2 to 1.5 cm wide. Along each angle is a leathery edge. Toothed trilobe leaves 2 to 5 cm wide appear at the nodes. Each has a tendril emerging from the opposite side of the node. Racemes of small white, yellowish, or greenish flowers; globular berries are red when ripe.


Has been used as a medicinal plant since antiquity. The Ayurveda mentions it as a tonic and analgesic, and prescribes its use to help heal broken bones, thus its name asthisamharaka (that which prevents the destruction of bones). Has also been used to treat osteoporosis, asthma, cough, hemorrhoids, and gonorrhea.

It contains a rich source of carotenoids, triterpenoids and ascorbic acid. Compounds that act as receptor antagonists of glucocorticoids have reduced the healing time of broken bones 30 to 50 percent in clinical trials. It has also been used to treat obesity and associated oxidative stress.[1] Its bactericidal effects on Helicobacter pylori hold promise as an effective treatment of gastric ulcers and preventative of stomach cancer in conjunction with NSAID therapy.[2]



  • Austin, A. Jegadeesan, M. Gowrishankar, R. (2004) "Helicobactericidal Activity of Cissus quadrangularis L. Variant I"; Natural Product Sciences 10 (5): 217-219. Korean Society of Pharmacognosy.
  • Chopra SS, Patel MR, Awadhiya RP. (1976) "Studies of Cissus quadrangularis in experimental fracture repair: a histopathological study"; Indian Journal of Medical Researches 64(9): 1365-1368.
  • Jainu, Mallika and Shyamala Devi (2003) "Tent antiulcerogenic activity of methanolic extract of Cissus quadrangularis by antioxidative mechanism"; ournal of Clinical Biochemistry and Nutrition, 34; 43-47.
  • Kashikar ND, George Indu (2006) "Antibacterial activity of Cissus quadrangularis Linn"; Indian Journal of Pharmaceutical Sciences 68 (2): 245-247.
  • Oben, Julius; Damaris Mandob Enyegue; Gilles I Fomekong; Yves B Soukontoua and Gabriel A Agbor (2007) "The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress"; Lipids in Health and Diseases 6: 4.
  • Sahelian, Ray (2006) "The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome"; Lipids in Health and Diseases 5: 24.

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