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Citicoline
Systematic (IUPAC) name
5'-O-[hydroxy({hydroxy[2-(trimethylammonio)ethoxy]
phosphoryl}oxy)phosphoryl]cytidine
Identifiers
CAS number 987-78-0 33818-15-4 (sodium salt)
ATC code N06BX06
PubChem 13805
ChemSpider 16736209
Chemical data
Formula C 14H27N4O11P2 +
Mol. mass 489.332 g/mol
SMILES eMolecules & PubChem
Synonyms Cytidine diphosphate choline
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
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Citicoline (INN), also known as cytidine diphosphate-choline (CDP-Choline) and cytidine 5'-diphosphocholine is a psychostimulant/nootropic. It is an intermediate in the generation of phosphatidylcholine from choline.

Studies suggest that CDP-choline supplements increase dopamine receptor densities, [1] and suggest that CDP-choline supplementation can ameliorate memory impairment caused by environmental conditions.[2] Preliminary research at Harvard found that citicoline supplements help improve focus and mental energy and may possibly be useful in the treatment of attention deficit disorder.[3]

It is an ingredient in some energy drinks such as "5-Hour Energy" and is available as an over the counter nutritional supplement.

Cognizin is the consumer brand for Citicoline produced by Kyowa Hakko Bio. Co., Ltd. and marketed as a dietary supplement and food ingredient by Kyowa Hakko U.S.A.

References

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