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City of Hope National Medical Center is one of 41 NCI-designated Cancer Centers and is located in the city of Duarte, California. City of Hope comprises an ambulatory and inpatient cancer treatment center as well as a biomedical research facility known as the Beckman Research Institute and the City of Hope Graduate School of Biological Sciences.

A major non-profit organization, City of Hope was originally founded in 1913 as a haven for those stricken with tuberculosis, as the dry, desert-like climate of the San Gabriel Valley was considered beneficial for those with the illness. Since then, the institution has grown to more than 300 physicians and scientists and over 2,500 employees, all of whom are part of City of Hope's work to find the causes of - and cures for - various forms of cancer as well as other life-threatening diseases, including diabetes and HIV/AIDS. For over 30 years, City of Hope physician services have been predominantly staffed by California Cancer Specialists Medical Group, Inc. With nearly 200 physicians, California Cancer Specialists provide the clinical and programmatic leadership in 18 medical specialties within City of Hope. The Group also provides clinical research and teaching services for the organization. The City of Hope campus is located on over 112 acres, and as of 2006, has 158 licensed beds, 84 of which are devoted to bone marrow transplantation patients.

City of Hope is a leader in translational research, and at any given time is conducting more than 300 clinical trials involving 30 to 40 percent of its eligible patients (compared to a national average of less than 5 percent). Some of the medical and scientific treatments based on research conducted at City of Hope include the drugs Herceptin, Rituxan, and Avastin. Additionally, a group of scientists at City of Hope lead by Arthur Riggs and Keiichi Itakura pioneered the research that led to the ability to produce synthetic human insulin. City of Hope is also an early pioneer in bone marrow transplantation, and has performed over 8000 bone marrow and stem cell transplants, making it one of the largest and most successful programs of its kind in the world.

On December 9, the City Of Hope National Medical Center was raided by the famous Animal Liberation Front causing possibly over $500,000 in damage because, as PETA president and spokesman for ALF said "They were used for painful exparements" "[The animals were] Emaciated, dehydrated, lethargic and unable to move." She stated.

Its primary medical center is the Helford Clinical Research Hospital, built in 2005. This 347,000 square foot, state-of-the-art facility provides immune-compromised patients high levels of attention and comfort, and is designed to enhance collaboration between physicians, caregivers, and clinical researchers. The hospital offers one of the largest units in the United States for performing hematopoietic cell transplantation (HCT), including stem cell and bone marrow transplantation (BMT). The facility’s 144 patient rooms are equipped to accommodate all but the most critical patients, making possible a high level of daily care.

The work performed at City of Hope is supported by public and private grants, fundraising events, as well as gifts from private donors. Its fundraising efforts are directed by its Development headquarters in downtown Los Angeles, as well as satellite offices in Seattle, San Francisco, Phoenix, San Diego, Chicago, Philadelphia and Ft. Lauderdale. More than 290,000 volunteers and donors worldwide support City of Hope and nearly 20 percent of its funding comes from private support through charitable contributions. A notable charity event is the Spring Luncheon Spirit of Life held annually in New York City. Recipients of the Spirit of Life Award include Alexander Crutchfield. In May 2009, cancer survivor and fashion designer Kay Unger will be presenting a runway show to increase awareness about leading medical cancer treatments within the fashion industry.

The hospital is located in Duarte, California. The main Development Center, is located in downtown Los Angeles.

The City of Hope's most famous patient is Anissa Ayala of Hacienda Heights, California, who (as a teenager in the early 1990s) was diagnosed with acute leukemia, so her parents decided to expand their family by giving Anissa a baby sister, Marissa, and using Marissa's umbilical cord cells to stop the spread of the leukemia. The plan was successful, and now Anissa is married and living in nearby San Bernardino County; her sister Marissa is now a high-school senior.

Affiliations

City of Hope is affiliated with the following institutions:

External links

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Coordinates: 34°08′10″N 117°59′26″W / 34.136084°N 117.990507°W / 34.136084; -117.990507

City of Hope
Formation 1913
Type NCI-designated Cancer Center
Purpose/focus Biomedical research, medical treatment, education
Headquarters 1500 E. Duarte Rd.
Duarte, Calif. 91010
President and CEO Michael A. Friedman, M.D.
Affiliations Association of Community Cancer Centers, National Cancer Institute-designated Comprehensive Cancer Center, National Comprehensive Cancer Network, National Bone Marrow Transplantation Research Network, National Gene Vector Laboratory, Southern California Islet Cell Consortium, Islet Cell Transplant Center, Juvenile Diabetes Research Foundation
Website http://www.cityofhope.org

The City of Hope National Medical Center, (referred to as simply City of Hope) is a biomedical research, treatment and education center dedicated to the prevention, treatment and cure of cancer and other life-threatening diseases[1].

The institution is one of 41 NCI-designated Cancer Centers[2], the highest designation[3] bestowed by the National Cancer Institute in recognition of excellence in cancer treatment, research, prevention and education, and a founding member[4] of the National Comprehensive Cancer Network, an alliance of cancer centers that defines and sets standards for cancer care in the United States[5].

City of Hope was founded in 1913 and is located in Duarte, California, United States, just northeast of Los Angeles, California.

Contents

Mission

File:Spirit of Life Fountain and Sculpture City of
Spirit of Life Fountain and Sculpture at main entrance to City of Hope

City of Hope
Los Angeles
City of Hope - Duarte (Los Angeles County, California)

City of Hope's mission is "to shorten the time from initial research idea to new treatment to quickly and effectively bring cures to patients who need them"[6].

Medical treatment

City of Hope reports treating more cancer patients than nearly any other institution in the state of California and maintains prostate, breast, hematology and musculoskeletal[citation needed] cancer programs that are among the largest in the state[7].

In the field of laparopscopic and robotic-assisted prostate surgeries, City of Hope states that their surgeons "have performed more (robotic urologic procedures) than any other center in the United States"[8].

City of Hope was a pioneer in bone marrow transplantation (BMT) and currently maintains one of the largest and most successful BMT programs in the world[9].

Clinical research

City of Hope is uniquely suited[10] to conducting translational research and ensuring that technological innovations are efficiently translated from the lab to the clinical setting[11]. Its on-site manufacturing facility, the Center for Biomedicine and Genetics, enables the rapid development of therapies created by City of Hope investigators and their collaborators[12].

At any given time, City of Hope conducts more than 300 clinical studies involving more than 40 percent of eligible patients, well above the U.S. national average of 5 percent[13]. City of Hope's clinical trials allow patients to benefit from new approaches to treatment[14].

Scientific breakthroughs

City of Hope has achieved numerous scientific breakthroughs and pioneered many lifesaving procedures that have benefited patients worldwide[15]. Numerous breakthrough cancer drugs, including Herceptin, Rituxan, Avastin and Erbitux, are based on technology pioneered by City of Hope[16] and are helping save lives worldwide[17][18][19][20].

Millions of people with diabetes benefit from synthetic human insulin developed through research conducted at City of Hope[21].

Facilities

File:Helford Hospital City of
City of Hope Helford Clinical Research Hospital

City of Hope Helford Clinical Research Hospital

Considered one of the most advanced cancer hospitals in the United States[citation needed], Helford Hospital is designed specifically to serve cancer patients and enable physicians and caregivers to provide attentive, effective care[22]. The hospital offers one of the largest specialized units in the nation for performing stem cell transplantation[23].

Beckman Research Institute

File:Beckman Research Institute City of
Beckman Research Institute at City of Hope

The first of only five[24] Beckman Research Institutes established by funding[25] from the Arnold and Mabel Beckman Foundation, City of Hope’s Beckman Research Institute works to expand the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes[26]. The institution has achieved breakthroughs in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies[27].

Center for Biomedicine & Genetics

A nationally renowned[28] (in the U.S.), technologically advanced manufacturing facility specializing in the production of pharmaceutical-grade materials, City of Hope’s Center for Biomedicine & Genetics fosters collaborations with other institutions and biopharmaceutical companies to develop and test new therapeutics[29]. The center also assists investigators in navigating the challenges inherent in translating research from early lab studies to clinical trials.

Irell & Manella Graduate School of Biological Sciences

City of Hope’s Irell & Manella Graduate School of Biological Sciences' mission is "to teach students to be outstanding research scientists in chemical, molecular, and cellular biology"[30]. With advanced teaching laboratories as classrooms and accomplished scientists as teachers and mentors[31], students participate in ongoing research that may be applied to the treatment and possible cure of life-threatening diseases.

Patient Housing

City of Hope states that they are "one of the few cancer centers in the (United States)" to offer patients and their caregivers temporary, on-site housing in a residential-style setting[32]. Parsons Village features fully equipped kitchens, 24-hour tram service, a computer room and lounge area for patients and their families. In addition, an RV park containing six spaces with full hookups to water, electricity, and disposal is available to all families[33].

Patients and their loved ones also benefit from the integrated services of the The Sheri & Les Biller Patient and Family Resources Center. Led by multidisciplinary teams of professionals and volunteers, the center reports offering "the most integrated array of support services in the country", including psychological and palliative[34].

Personnel

City of Hope is composed of more than 200 physicians and scientists and employs over 3,000 people. It maintains fundraising offices in Los Angeles, Palm Desert, San Francisco, San Diego, Phoenix, Seattle, Chicago, Philadelphia and South Florida. The hospital currently has 217 licensed, and 183 staffed, beds. More than 300,000+ volunteers and donors worldwide support the lifesaving mission of City of Hope.

Affiliations

City of Hope is affiliated with the following institutions:

  • Association of Community Cancer Centers
  • National Cancer Institute-designated Comprehensive Cancer Center
  • National Comprehensive Cancer Network (founding member)
  • National Bone Marrow Transplantation Research Network (founding member)
  • National Gene Vector Laboratory
  • Southern California Islet Cell Consortium
  • Islet cell transplant center, Juvenile Diabetes Research Foundation

Awards

  • City of Hope is ranked as one of “America’s Best Hospitals” in cancer and urology by U.S.News & World Report[35].
  • City of Hope received full accreditation by the Joint Commission, the nation's most widely recognized health care accrediting body.
  • City of Hope is one of only eight cancer hospitals nationwide listed as AARP Magazine’s “Doctors Faves” -- hospitals that doctors indicated they are most likely to refer patients to for extremely difficult cancer cases.
  • Numerous City of Hope physicians are featured in “America’s Top Doctors for Cancer,” a consumer guide to the nation’s top cancer specialists.

Grants

  • A five year, $11.5 million Specialized Program of Research Excellence (SPORE) grant was awarded to City of Hope from the National Cancer Institute (NCI) to for translational research studies for Hodgkin and non-Hodgkin lymphoma. City of Hope is the only research institute and cancer center in California to have received this prestigious grant for the research and treatment of lymphomas.
  • The California Institute for Regenerative Medicine (CIRM) awarded City of Hope nearly $32.6 million in grants for research into potential therapies for AIDS-related lymphoma and brain cancer.
  • City of Hope’s Department of Information Sciences has been granted almost $17 million from the National Library of Medicine and the National Institute of Diabetes and Digestive and Kidney Diseases to serve as a coordinating center for distribution of islet cells and intestinal stem cells.
  • The NCI awarded City of Hope’s Division of Nursing Research $13.4 million for a five-year study on palliative care and quality-of-life concerns for lung cancer patients.
  • City of Hope’s Division of Cancer Etiology has been awarded nearly $5 million over three years by the NCI for the California Teachers Study, a survey of over 130,000 public school teachers or administrators to study the link between obesity, physical activity, hormone exposure and cancer.
  • City of Hope’s Department of Population Sciences was awarded $3.4 million over five years from the NCI to study whether there’s a genetic susceptibility for cancer survivors to develop secondary malignancies as a result of their treatments.
  • The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded City of Hope an $8.6 million contract to facilitate stem cell research from laboratory to clinical study. The five-year contract is the first from the NHLBI to focus on development and manufacturing of stem cell therapies.
  • The National Institute of Environmental Health Sciences has awarded City of Hope $2 million for a study of ultraviolet light damage and its effect on mutagenesis.

See also

References

  1. ^ About City of Hope, an National Cancer Institute-designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network.
  2. ^ Cancer Centers Program - Cancer Centers List.
  3. ^ NCI-designated Cancer Center "The standards for Comprehensive Cancer Centers are the more restrictive of the two types."
  4. ^ See Institutional Distinctions.
  5. ^ NCCN Guidelines.
  6. ^ NCCN Institution Profile - City of Hope Comprehensive Cancer Center.
  7. ^ Institutional Distinctions. "City of Hope maintains the No. 1 hematology program and the No. 1 prostate cancer program in California, and ranks No. 2 in the state for its breast cancer program, based on the number of patients treated. Source: Office of Statewide Planning and Development."
  8. ^ Research and Treatment Milestones. "Since 2000, City of Hope physicians have performed more radical prostatectomies than any other center in the U.S."
  9. ^ Research and Treatment Milestones "A pioneer in bone marrow transplantation, City of Hope has performed more than 9,000 bone marrow transplants, and today operates one of the largest, most successful programs of its kind in the world."
  10. ^ New York Times. "The City of Hope National Medical Center in Duarte, Calif., has set up a factory to make experimental drugs for use in clinical trials in compliance with government regulations." Andrew Pollack. 31 July 2003. Three Universities Join Researcher To Develop Drugs. The New York Times.
  11. ^ Center for Biomedicine and Genetics. City of Hope maintains an on-site drug manufacturing facility, the Center for Biomedicine and Genetics, which "ensure(s) that (City of Hope) technological innovations are efficiently translated from the research lab to the clinical setting in a cost-effective and expeditious manner". See Center for Biomedicine and Genetics
  12. ^ Center for Biomedicine and Genetics
  13. ^ Institutional Distinctions. "City of Hope conducts more than 300 clinical studies, involving 30 to 40 percent of its eligible patients. The national average is less than 5 percent[citation needed]."
  14. ^ City of Hope Patient-centered Research. "Although driven to find new and improved therapies, [City of Hope's] focus remains on ... patients. The Phase I Clinical Trials Program often offers options to patients who have few choices, giving them a ray of hope and a chance to contribute to improving treatments for future patients in a compassionate and safe environment of care."
  15. ^ Recent Research Breakthroughs
  16. ^ City of Hope Research - Beckman Research Institute and City of Hope Comprehensive Cancer Center - located near Los Angeles, California "Our research also made possible the widely used cancer fighting drugs, Herceptin, Rituxan and Avastin."
  17. ^ Herceptin#Impact
  18. ^ Rituxan#Autoimmune diseases
  19. ^ Avastin#Indications
  20. ^ Erbitux#Indications
  21. ^ City of Hope Research - Beckman Research Institute and City of Hope Comprehensive Cancer Center - located near Los Angeles, California "We helped launch the biotech industry with the development of technologies that led to the first synthetic human insulin and human growth hormone."
  22. ^ Helford Clinical Research Hospital-City of Hope "Designed specifically to serve cancer patients and enable physicians and caregivers to provide the most attentive, effective care..."
  23. ^ Helford Clinical Research Hospital-City of Hope "the hospital offers one of the largest units in the United States for performing hematopoietic cell transplantation (HCT), including stem cell and bone marrow transplantation (BMT)."
  24. ^ Beckman Research Institute of City of Hope "The first of only five Beckman Research Institutes..."
  25. ^ Beckman Research Institute of City of Hope "...established by funding from the Arnold and Mabel Beckman Foundation..."
  26. ^ Beckman Research Institute of City of Hope "...we are responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes."
  27. ^ Beckman Research Institute of City of Hope "Our breakthroughs in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies are testaments to the culture of collaboration that inspires and informs our work."
  28. ^ Center for Biomedicine and Genetics (CBG) - City of Hope "CBG is recognized as the nation's premier academic biologic manufacturing facility (the “gold standard” for such facilities, according to the Food and Drug Administration), and has been lauded by The New York Times for its leading role in devising innovative methods of rapid drug development."
  29. ^ Center for Biomedicine and Genetics (CBG) - City of Hope
  30. ^ City of Hope Irell & Manella Graduate School of Biological Sciences - Biology Graduate School, Cancer Biology Graduate School "The mission of the City of Hope Irell & Manella Graduate School of Biological Sciences is to teach students to be outstanding research scientists in chemical, molecular, and cellular biology."
  31. ^ Faculty "The faculty at City of Hope’s Irell & Manella Graduate School of Biological Sciences is a diverse and distinguished group. They hail from the finest universities and research institutions, have received numerous awards and accolades, and have had their research published in the most prestigious peer-reviewed journals. The varied backgrounds of our faculty members assure graduate students of a comprehensive, multidisciplinary educational experience."
  32. ^ Hope and Parsons Village "City of Hope is one of the few cancer centers in the country to offer patients and their caregivers temporary, on-site housing in a comfortable, home-like setting."
  33. ^ Hope and Parsons Village
  34. ^ The Sheri & Les Biller Patient and Family Resources Center at City of Hope "it offers the most integrated array of support services in the country"
  35. ^ US News & World Report. "Out of the 4,861 facilities analyzed in compiling the 2009 edition of America's Best Hospitals, only 174 were ranked in any of 16 adult specialties. [City of Hope] was one of them." City of Hope National Medical Center. 2010. City of Hope, Duarte, Calif.. US News & World Report. Retrieved 12 July 2010 from http://health.usnews.com/best-hospitals/city-of-hope-national-medical-center-6930590

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