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Class I PI 3-kinases: Wikis


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Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.


Class IA PI 3-kinases

Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).

There are three catalytic subunits which are classified as class IA PI 3-kinases:

There are currently five regulatory subunits which are known to associate with class IA PI 3-kinases catalytic subunits:

Class IB PI 3-kinases

Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs)

The only known class IB PI 3-kinase catalytic subunit is p110γ

There are two known regulatory subunits for p110γ:

See also


  • Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family". J. Cell. Sci. 116 (Pt 15): 3037–40. doi:10.1242/jcs.00609. PMID 12829733.  


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