Clean Fuels Ohio (CFO) is a non-profit organization, formed in January 2002 under the original name of Central Ohio Clean fuels Coalition (COCFC). It is currently based at The Ohio State University Center for Automotive Research. Its mission is to increase the use of cleaner American fuels and vehicles and energy-saving transportation technologies (AFVTs) in order to improve air quality and health, reduce climate change, curb dependence on imported petroleum, and support Ohio’s economy. Clean American fuels include biodiesel, natural gas, propane, ethanol, electricity, and hydrogen. In 2002, the U.S. Department of Energy designated CFO as the Clean Cities coalition for Central Ohio. The DOE also gave an award to the Coalition in 2002 for "one of the best (market development) program plans ever received."

Clean Fuels Ohio's primary goal is to develop public-private projects that deploy vehicles, refueling equipment, and other technologies. These projects are meant to lead directly to improved air quality, reduction in greenhouse gas emissions, increased energy security and support for Ohio’s economy. As part of this goal, CFO educates government and private fleet decision-makers, operations and maintenance personnel, teachers, students, public officials, the media and the general public. CFO also supports government policies that are consistent with its mission.