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Clebopride: Wikis

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Clebopride
Systematic (IUPAC) name
4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-
2-methoxybenzamide
Identifiers
CAS number 55905-53-8
ATC code A03FA06
PubChem 2780
ChemSpider 2678
Chemical data
Formula C 20H24ClN3O2  
Mol. mass 373.876 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Clebopride is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders. Chemically, it is a substituted benzamide, closely related to metoclopramide.

A small Spanish study found that more adverse reactions are reported with clebopride than with metoclopramide, particularly extrapyramidal symptoms.[1]

References

  1. ^ Cuena Boy R, Maciá Martínez MA (1998). "[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]" (in Spanish). Atencion Primaria 21 (5): 289–95. PMID 9608114.   Free full text
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