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Clobenpropit
Clobenpropit.svg
IUPAC name
Identifiers
CAS number 145231-45-4
PubChem 2790
SMILES
Properties
Molecular formula C14H17ClN4S
Molar mass 308.83 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Clobenpropit is a histamine H3 antagonist.[1] It has neuroprotective effects via stimulation of GABA release in the brain.[2]

References

  1. ^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". Eur. J. Pharmacol. 567 (3): 206–10. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.  
  2. ^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613
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