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Clobetasol propionate: Wikis


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Clobetasol propionate
Systematic (IUPAC) name
[17-(2'-chloroacetyl)- 9-fluoro-11-hydroxy-10,13,16-trimethyl- 3-oxo-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
CAS number 25122-46-7
ATC code D07AD01
PubChem 32798
DrugBank APRD00876
ChemSpider 30399
Chemical data
Formula C 25H32ClFO5  
Mol. mass 466.97 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat. C (US)
Legal status Rx Only
Routes Topical
 Yes check.svgY(what is this?)  (verify)

Clobetasol propionate is a corticosteroid used to treat various skin disorders including eczema and psoriasis. Clobetasol belongs to Class I (Super Potent) of the corticosteroids, making it one of the most potent available. It comes in ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules).

Clobetasol propionate is marketed and sold worldwide under numerous names including Clobex, Cosvate (India), Temovate (US),Olux, Tenovate, Dermovate, Dermatovate, Butavate, Movate, in China: 丙咪氯苯乳膏 (cream) and 复方丙酸氯倍他索搽剂 (liquid).

Phonetic pronunciation: kloh-BAY-tuh-sall[1]



  • Clobetasol propionate ointment USP 0.05%, supplied in Olux 15 g, 30 g, 45 g, and 60 g tubes.
  • Temovate & emollient 0.05%, supplied in 15 g (NDC 0173-0454-01), 30 g (NDC 0173-0454-02) and 60 g (NDC 0173-0454-03) tubes.
  • Clobetasol propionate foam 0.05%
  • Clobetasol propionate cream 0.05%
  • Clobetasol propionate gel 0.05%
  • Clobestasol propianate spray 0.05%
  • Dermovate cream and ointment, containing Clobetasol propionate 0.05% (UK)
  • Dermol cream and ointment (NZ)

Possible side effects

Most important facts about Clobetasol Propionate

This medication is to be used as directed by a physician. It is for external use only. Keep out of eyes.[2] When using Clobetasol Propionate some of it may be absorbed through the skin and into the bloodstream. Too much absorption may lead to unwanted side effects. To minimize the problem large amounts of Clobetasol Propionate should not be used over large areas. Airtight dressings or adhesive bandages are not recommended unless specifically told to by a doctor.[3] Any signs of adverse reactions should be reported to the prescribing physician.

Risk to pregnant women

According to the California Environmental Protection Agency, clobetasol propionate should not be used by pregnant women, or women expecting to become pregnant soon, as studies with rats shows a risk of birth defects:[4]

"Studies in the rat following oral administration at dosage levels up to 50 mg/kg per day revealed that the females exhibited an increase in the number of resorbed embryos and a decrease in the number of living fetuses at the highest dose. Pregnancy: Teratogenic Effects (i.e., possibility of causing abnormailities in fetuses): Pregnancy Category C: Clobetasol propionate has not been tested for teratogenicity when applied topically; however, it is absorbed percutaneously, and when administered subcutaneously it was a significant teratogen in both the rabbit and mouse. Clobetasol propionate has greater teratogenic potential than steroids that are less potent.There are no adequate and well-controlled studies of the teratogenic effects of clobetasol propionate in pregnant women. Temovate Cream and Ointment should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus."

External links

  • [1]Material Safety Data Sheet(MSDS)
  • [2]Manufacturers Product Information Sheet
  • [3]Manufacturers Product Web Page


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