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Clotiazepam: Wikis

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Systematic (IUPAC) name
2-(2-chlorophenyl)- 9-ethyl- 6-methyl- 8-thia- 3,6-diazabicyclo[5.3.0] deca- 2,9,11-trien- 5-one
CAS number 33671-46-4
ATC code N05BA21
PubChem 2811
DrugBank ?
ChemSpider 2709
Chemical data
Formula C 16H15ClN2OS 
Mol. mass 318.8 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule IV (US)
Routes Oral
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Clotiazepam (marketed under brand name Clozan, Distensan, Trecalmo, Rize, Rizen and Veratran) is a thienodiazepine drug which is a benzodiazepine analog. The clotiazepam molecule differs from most other benzodiazepines in that the benzene ring has been replaced by a thiophene ring.[1] It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Stage 2 NREM sleep is significantly increased by clotiazepam.[2]

Clotiazepam is not approved for sale in the United States or Canada.

See also


  1. ^ Niwa T, Shiraga T, Ishii I, Kagayama A, Takagi A (September 2005). "Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs" (PDF). Biol. Pharm. Bull. 28 (9): 1711–6. doi:10.1248/bpb.28.1711. PMID 16141545.  
  2. ^ Nakazawa Y; Kotorii M, Oshima M, Horikawa S, Tachibana H. (October 31, 1975). "Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives.". Psychopharmacologia. 44 (2): 165–71. doi:10.1007/BF00421005. PMID 709.  

External links

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