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Cloxacillin: Wikis

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Cloxacillin
Systematic (IUPAC) name
(2S,5R,6R)-6-{[3-(2-chlorophenyl)-5-methyl-
oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo-
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Identifiers
CAS number 61-72-3
ATC code J01CF02 QJ51CF02 QS01AA90
PubChem 6098
DrugBank APRD00882
ChemSpider 5873
Chemical data
Formula C 19H18ClN3O5S 
Mol. mass 435.88 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 37 to 90%
Protein binding 95%
Metabolism  ?
Half life 30 minutes to 1 hour
Excretion Renal and biliary
Therapeutic considerations
Pregnancy cat. B(US)
Legal status
Routes Oral, IM
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Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin was discovered and developed by Beecham. It is sold under a number of trade names, including Cloxapen and Orbenin.

Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain which doesn't allow the beta-lactamases to bind.

This drug has a weaker antibacterial activity than benzylpenicillin, and is devoid of serious toxicity except for allergic reactions.

It has been suggested, in one study, that increased use of cloxacillin may permit reduced use of vancomycin.[1]

See also

References

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