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Codorphone: Wikis


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Systematic (IUPAC) name
(1S,13R,16S,17 R)- 4-(cyclopropylmethyl)- 16-ethyl- 10-methoxy- 12-oxa- 4-azapentacyclo [,13.05,17.07,18] octadeca- 7(18),8,10- trien- 14-one
CAS number 70865-14-4
ATC code none
PubChem 5361887
Chemical data
Formula C 23H29NO3  
Mol. mass 367.481 g/mol
SMILES eMolecules & PubChem
Synonyms (5α,8β)-17- Cyclopropylmethyl- 4,5-epoxy- 8-ethyl- 3-methoxy- morphinan- 6-one
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Codorphone (Conorphone) is an opioid analgesic drug. It is an analogue of hydrocodone substituted with an 8-ethyl group and an N-cyclopropylmethyl group. It is a mixed agonist-antagonist at the μ-opioid receptor, and is slightly more potent than codeine in analgesic effects but associated with somewhat greater side effects.[1]


  1. ^ Dionne RA, Wirdezk PR, Butler DP, Fox PC. Comparison of conorphone, a mixed agonist-antagonist analgesic, to codeine for postoperative dental pain. Anesthesia Progress. 1984 Mar-Apr;31(2):77-81. PMID 6597688


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