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Systematic (IUPAC) name
(((4,5α- Epoxy- 3-methoxy- 17-methylmorphinan- 6-ylidene) amino)oxy) acetic acid
CAS number 7125-76-0
ATC code none
PubChem 9570253
Chemical data
Formula C 20H24N2O5  
Mol. mass 372.415 g/mol
SMILES eMolecules & PubChem
Synonyms Codoxime
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Codoxime (Codossima) is an opiate analogue that is a derivative of hydrocodone, where the 6-ketone group has been replaced by carboxymethyloxime. It has primarily antitussive effects[1] and was found to have moderate potential to cause dependence in animal studies.[2]


  1. ^ Jack Fishman. Morphinone and Codeinone Derivatives. US Patent 3153042
  2. ^ Jasinski DR, Martin WR. Assessment of the dependence-producing properties of dihydrocodeinone and codoxime. Clinical Pharmacology and Therapeutics. 1967 Mar-Apr;8(2):266-70. PMID 6021586


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