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Complement receptor 2: Wikis


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Complement component (3d/Epstein Barr virus) receptor 2

PDB rendering based on 1ghq.
Available structures
1ghq, 1ly2, 1w2r, 1w2s, 2gsx
Symbols CR2; C3DR; CD21
External IDs OMIM120650 MGI88489 HomoloGene55611 GeneCards: CR2 Gene
RNA expression pattern
PBB GE CR2 205544 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1380 12902
Ensembl ENSG00000117322 ENSMUSG00000026616
UniProt P20023 Q6LAP4
RefSeq (mRNA) NM_001006658 NM_007758
RefSeq (protein) NP_001006659 NP_031784
Location (UCSC) Chr 1:
205.69 - 205.73 Mb
Chr 1:
196.84 - 196.88 Mb
PubMed search [1] [2]

Complement component (3d/Epstein Barr virus) receptor 2, also known as CR2 and CD21, is a protein involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d.[1] B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation [2]

CR2 on mature B cells form a complex with two other membrane proteins, CD19 and CD81(=TAPA-1). The CR2-CD19-CD81 complex is often called the B cell coreceptor complex,[3] because CR2 binds to antigens through attached C3d (or iC3b or C3dg) when the membrane IgM binds to the antigen. This results in the B cell to have greatly enhanced response to the antigen.[1]

Epstein-Barr virus (EBV) binds to B cells at CR2 during infection of these cells. Yefenof et al. (1976) found complete overlapping of EBV receptors and C3 receptors on human B lymphocytes.[4][2]



Complement receptor 2 has been shown to interact with CD19.[5][6]


  1. ^ a b Frank K, Atkinson JP (2001). "Complement system." In Austen KF, Frank K, Atkinson JP, Cantor H. eds. Samter's Immunologic Diseases, 6th ed. Vol. 1, p. 281-298, Philadelphia: Lippincott Williams & Wilkins, ISBN 0781721202.
  2. ^ a b "Entrez Gene: CR2 complement component (3d/Epstein Barr virus) receptor 2".  
  3. ^ Abbas AK, Lichtman AH (2003). Cellular and Molecular Immunology, 5th ed. Philadelphia: Saunders, ISBN 0721600085
  4. ^ Yefenof E, Klein G, Jondal M, Oldstone MB (June 1976). "Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines". Int. J. Cancer 17 (6): 693?700. doi:10.1002/ijc.2910170602. PMID 181330.  
  5. ^ Bradbury, L E; Kansas G S, Levy S, Evans R L, Tedder T F (Nov. 1992). "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules". J. Immunol. (UNITED STATES) 149 (9): 2841–50. ISSN 0022-1767. PMID 1383329.  
  6. ^ Horváth, G; Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (Nov. 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". J. Biol. Chem. (UNITED STATES) 273 (46): 30537–43. ISSN 0021-9258. PMID 9804823.  

Further reading

  • Cooper NR, Bradt BM, Rhim JS, Nemerow GR (1990). "CR2 complement receptor.". J. Invest. Dermatol. 94 (6 Suppl): 112S?117S. doi:10.1111/1523-1747.ep12876069. PMID 2161885.  
  • Yefenof E, Klein G, Jondal M, Oldstone MB (1976). "Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines.". Int. J. Cancer 17 (6): 693?700. doi:10.1002/ijc.2910170602. PMID 181330.  
  • Gauffre A, Viron A, Barel M, et al. (1992). "Nuclear localization of the Epstein-Barr virus/C3d receptor (CR2) in the human Burkitt B lymphoma cell, Raji.". Mol. Immunol. 29 (9): 1113?20. doi:10.1016/0161-5890(92)90044-X. PMID 1323059.  
  • Bradbury LE, Kansas GS, Levy S, et al. (1992). "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.". J. Immunol. 149 (9): 2841?50. PMID 1383329.  
  • Levy E, Ambrus J, Kahl L, et al. (1992). "T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE).". Clin. Exp. Immunol. 90 (2): 235?44. PMID 1424280.  
  • Matsumoto AK, Kopicky-Burd J, Carter RH, et al. (1991). "Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.". J. Exp. Med. 173 (1): 55?64. doi:10.1084/jem.173.1.55. PMID 1702139.  
  • Tuveson DA, Ahearn JM, Matsumoto AK, Fearon DT (1991). "Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex.". J. Exp. Med. 173 (5): 1083?9. doi:10.1084/jem.173.5.1083. PMID 1708808.  
  • Kalli KR, Ahearn JM, Fearon DT (1991). "Interaction of iC3b with recombinant isotypic and chimeric forms of CR2.". J. Immunol. 147 (2): 590?4. PMID 1830068.  
  • Barel M, Gauffre A, Lyamani F, et al. (1991). "Intracellular interaction of EBV/C3d receptor (CR2) with p68, a calcium-binding protein present in normal but not in transformed B lymphocytes.". J. Immunol. 147 (4): 1286?91. PMID 1831222.  
  • Delcayre AX, Salas F, Mathur S, et al. (1991). "Epstein Barr virus/complement C3d receptor is an interferon alpha receptor.". Embo J. 10 (4): 919?26. PMID 1849076.  
  • Kurtz CB, Paul MS, Aegerter M, et al. (1989). "Murine complement receptor gene family. II. Identification and characterization of the murine homolog (Cr2) to human CR2 and its molecular linkage to Crry.". J. Immunol. 143 (6): 2058?67. PMID 2528587.  
  • Fujisaku A, Harley JB, Frank MB, et al. (1989). "Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor.". J. Biol. Chem. 264 (4): 2118?25. PMID 2563370.  
  • Moore MD, Cooper NR, Tack BF, Nemerow GR (1988). "Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9194?8. doi:10.1073/pnas.84.24.9194. PMID 2827171.  
  • Weis JJ, Toothaker LE, Smith JA, et al. (1988). "Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins.". J. Exp. Med. 167 (3): 1047?66. doi:10.1084/jem.167.3.1047. PMID 2832506.  
  • Weis JJ, Fearon DT, Klickstein LB, et al. (1986). "Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement.". Proc. Natl. Acad. Sci. U.S.A. 83 (15): 5639?43. doi:10.1073/pnas.83.15.5639. PMID 3016712.  
  • Weis JH, Morton CC, Bruns GA, et al. (1987). "A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.". J. Immunol. 138 (1): 312?5. PMID 3782802.  
  • Aubry JP, Pochon S, Gauchat JF, et al. (1994). "CD23 interacts with a new functional extracytoplasmic domain involving N-linked oligosaccharides on CD21.". J. Immunol. 152 (12): 5806?13. PMID 7515913.  
  • Matsumoto AK, Martin DR, Carter RH, et al. (1993). "Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.". J. Exp. Med. 178 (4): 1407?17. doi:10.1084/jem.178.4.1407. PMID 7690834.  
  • Barel M, Balbo M, Gauffre A, Frade R (1995). "Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein.". Mol. Immunol. 32 (6): 389?97. doi:10.1016/0161-5890(95)00005-Y. PMID 7753047.  

See also

External links



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