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A corepressor is a protein that decreases gene expression by binding to a transcription factor which contains a DNA binding domain. The corepressor is unable to bind DNA by itself. The corepressor can repress transcriptional initiation by recruiting histone deacetylases which catalyze the removal of acetyl groups from lysine residues. This increases the positive charge on histones which strengthens in the interaction between the histones and DNA, making the latter less accessible to transcription.[1][2]


  1. ^ Lazar MA (2003). "Nuclear receptor corepressors". Nucl Recept Signal 1 (Jun 12): e001. doi:10.1621/nrs.01001. PMID 16604174.  
  2. ^ Goodson M, Jonas BA, Privalsky MA (2005). "Corepressors: custom tailoring and alterations while you wait". Nucl Recept Signal 3 (Oct 21): e003. doi:10.1621/nrs.03003. PMID 16604171.  

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