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Cyclic AMP receptors: Wikis


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Slime mold cyclic AMP receptor
Symbol Dicty_CAR
Pfam PF05462
InterPro IPR000848

Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors. These receptors control development in Dictyostelium discoideum.

The cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes[1][2][3]. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.


  1. ^ Devreotes PN, Kimmel AR, Johnson RL, Klein PS, Sun TJ, Saxe III CL (1988). "A chemoattractant receptor controls development in Dictyostelium discoideum". Science 241 (4872): 1467–1472. doi:10.1126/science.3047871. PMID 3047871.  
  2. ^ Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR, Saxe III CL (1993). "CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum". Genes Dev. 7 (2): 262–272. doi:10.1101/gad.7.2.262. PMID 8436297.  
  3. ^ Devreotes PN, Kimmel AR, Johnson RL, Gollop R, Saxe III CL (1993). "Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development". Genes Dev. 7 (2): 273–282. doi:10.1101/gad.7.2.273. PMID 8382181.  


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