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Cyclic nucleotide-gated channel alpha 1: Wikis


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Cyclic nucleotide-gated channel alpha 1
Symbols CNGA1; CNCG; CNCG1; CNG1; RCNC1; RCNCa; RCNCalpha
External IDs OMIM123825 MGI88436 HomoloGene55432 IUPHAR: CNGA1 GeneCards: CNGA1 Gene
RNA expression pattern
PBB GE CNGA1 206417 at tn.png
More reference expression data
Species Human Mouse
Entrez 1259 12788
Ensembl ENSG00000198515 ENSMUSG00000067220
UniProt P29973 Q5U408
RefSeq (mRNA) NM_000087 NM_007723
RefSeq (protein) NP_000078 NP_031749
Location (UCSC) Chr 4:
47.63 - 47.68 Mb
Chr 5:
72.88 - 72.92 Mb
PubMed search [1] [2]

Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.[1]


See also


Further reading

  • Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.  
  • Pittler SJ, Lee AK, Altherr MR, et al. (1992). "Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel.". J. Biol. Chem. 267 (9): 6257–62. PMID 1372902.  
  • Arsenault TV, Sauder DN, Harley CB, McKenzie RC (1992). "Identification and characterization of a partial cDNA expressing interleukin-1-like activity in keratinocytes.". Mol. Immunol. 29 (3): 431–8. doi:10.1016/0161-5890(92)90031-R. PMID 1372959.  
  • Dhallan RS, Macke JP, Eddy RL, et al. (1992). "Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression.". J. Neurosci. 12 (8): 3248–56. PMID 1379636.  
  • Dryja TP, Finn JT, Peng YW, et al. (1995). "Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10177–81. doi:10.1073/pnas.92.22.10177. PMID 7479749.  
  • Distler M, Biel M, Flockerzi V, Hofmann F (1995). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells.". Neuropharmacology 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814.  
  • Griffin CA, Ding CL, Jabs EW, et al. (1993). "Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization.". Genomics 16 (1): 302–3. doi:10.1006/geno.1993.1187. PMID 7683629.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Paloma E, Martínez-Mir A, García-Sandoval B, et al. (2002). "Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa.". J. Med. Genet. 39 (10): E66. doi:10.1136/jmg.39.10.e66. PMID 12362048.  
  • Cheng CH, Yew DT, Kwan HY, et al. (2003). "An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA.". Mol. Biol. Cell 13 (10): 3696–705. doi:10.1091/mbc.E02-03-0127. PMID 12388767.  
  • Zhong H, Molday LL, Molday RS, Yau KW (2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry.". Nature 420 (6912): 193–8. doi:10.1038/nature01201. PMID 12432397.  
  • Zheng J, Trudeau MC, Zagotta WN (2003). "Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit.". Neuron 36 (5): 891–6. doi:10.1016/S0896-6273(02)01099-1. PMID 12467592.  
  • Kang K, Bauer PJ, Kinjo TG, et al. (2003). "Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs.". Biochemistry 42 (15): 4593–600. doi:10.1021/bi027276z. PMID 12693957.  
  • Zhang Q, Zulfiqar F, Riazuddin SA, et al. (2005). "Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation.". Mol. Vis. 10: 884–9. PMID 15570217.  
  • Shi F, Perez E, Wang T, et al. (2005). "Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis.". J. Androl. 26 (2): 258–63. PMID 15713832.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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